ARACHIDONIC-ACID INDUCED INCREASE IN INTRACELLULAR FREE CALCIUM IN GUINEA-PIG HEPATOCYTES

被引：7
|
作者：
HIRANO, Y [1 ]
ABE, S [1 ]
SAWANOBORI, T [1 ]
HIRAOKA, M [1 ]
机构：
[1] TOKYO MED & DENT UNIV,DEPT INTERNAL MED 2,BUNKYO KU,TOKYO 113,JAPAN
来源：
JAPANESE JOURNAL OF PHYSIOLOGY | 1991年 / 41卷 / 02期
关键词：
ARACHIDONIC ACID; HEPATOCYTE; FURA-2;
D O I：
10.2170/jjphysiol.41.327
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Arachidonic acid (AA) caused elevations of intracellular free Ca2+ concentration ([Ca2+]i) measured by fura-2 fluorescence digital imaging microscopy in isolated guinea-pig hepatocytes. AA-induced increase in [Ca2+]i could still be observed when extracellular Ca2+ was chelated by EGTA, and was not influenced by either cyclooxygenase or lipoxygenase inhibitors. These results suggest that AA itself rather than its metabolites has direct effects on intracellular Ca2+ mobilization, causing the elevation of [Ca2+]i.
引用
收藏
页码：327 / 332
页数：6
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