ARACHIDONIC-ACID INDUCED INCREASE IN INTRACELLULAR FREE CALCIUM IN GUINEA-PIG HEPATOCYTES

被引：7

作者：

HIRANO, Y ^{[1
]}

ABE, S ^{[1
]}

SAWANOBORI, T ^{[1
]}

HIRAOKA, M ^{[1
]}

机构：

[1] TOKYO MED & DENT UNIV,DEPT INTERNAL MED 2,BUNKYO KU,TOKYO 113,JAPAN

来源：

JAPANESE JOURNAL OF PHYSIOLOGY | 1991年 / 41卷 / 02期

关键词：

ARACHIDONIC ACID; HEPATOCYTE; FURA-2;

D O I：

10.2170/jjphysiol.41.327

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Arachidonic acid (AA) caused elevations of intracellular free Ca2+ concentration ([Ca2+]i) measured by fura-2 fluorescence digital imaging microscopy in isolated guinea-pig hepatocytes. AA-induced increase in [Ca2+]i could still be observed when extracellular Ca2+ was chelated by EGTA, and was not influenced by either cyclooxygenase or lipoxygenase inhibitors. These results suggest that AA itself rather than its metabolites has direct effects on intracellular Ca2+ mobilization, causing the elevation of [Ca2+]i.

引用

页码：327 / 332

页数：6

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