SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW MANNICH BASES OF 7-ACYL-5-CHLORO-2-OXO-3H-BENZOXAZOLE DERIVATIVES

被引：0
|
作者：
Nacak, Sultan [1 ]
Okcelik, Berna [1 ]
Unlu, Serdar [1 ]
Sahin, M. Fethi [1 ]
Ozkan, Semiha [2 ]
Abbasoglu, Ufuk [2 ]
机构：
[1] Gazi Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06330 Hipodrom Ankara, Turkey
[2] Gazi Univ, Fac Pharm, Dept Pharmaceut Microbiol, TR-06330 Hipodrom Ankara, Turkey
来源：
TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES | 2005年 / 2卷 / 01期
关键词：
Mannich bases; benzoxazole; antibacterial; antifungal;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A series of novel Mannich bases of 7-acyl-5-chloro-2-oxo-3H-benzoxazoles were synthesized by reacting them with formaldehyde and several seconder amine derivatives. Their chemical structures were elucidated by means of their IR, H-1-NMR data and by elemental analysis. Investigation of in vitro antimicrobial activity of compounds was done by broth microdilution method against six pathogenic bacteria.
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页码：25 / 33
页数：9
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