PENILE ERECTION AND YAWNING INDUCED BY PARAVENTRICULAR NMDA INJECTION IN MALE-RATS ARE MEDIATED BY OXYTOCIN

被引：48

作者：

MELIS, MR ^{[1
]}

STANCAMPIANO, R ^{[1
]}

ARGIOLAS, A ^{[1
]}

机构：

[1] UNIV CAGLIARI,BB BRODIE DEPT NEUROSCI,I-09124 CAGLIARI,ITALY

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1994年 / 48卷 / 01期

关键词：

GLUTAMIC ACID; NMDA; OXYTOCIN; PENILE ERECTION; YAWNING; PARAVENTRICULAR NUCLEUS; RAT;

D O I：

10.1016/0091-3057(94)90517-7

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The effect of N-methyl-D-aspartic acid (NMDA), (+/-)-alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA), or (+/-)-trans-1-amino-1,3-cyclo-pentanedicarboxylic acid (ACPD) (5-60 ng in 0.3 mu l of saline) microinjected in the paraventricular nucleus of the hypothalamus on penile erection and yawning was studied in male rats. NMDA induced both penile erection and yawning in a dose-dependent manner. AMPA and ACPD also induced penile erection but less potently than NMDA, but were ineffective in causing yawning. NMDA effect on penile erection and yawning was prevented by (+)-MK-801 (0.05-0.1 mg/kg IP, 10 min before NMDA), by the oxytocin antagonist d(CH2)(5)Tyr(Me)-Orn(8)-vasotocin (50-100 ng ICV 10 min before NMDA), but not by haloperidol (0.1-0.5 mg/kg IP 10 min before NMDA). The results suggest that NMDA induces penile erection and yawning by increasing oxytocinergic transmission by acting in the paraventricular nucleus of the hypothalamus.

引用

页码：203 / 207

页数：5

共 30 条

[1] PARAVENTRICULAR NUCLEUS LESION PREVENTS YAWNING AND PENILE ERECTION INDUCED BY APOMORPHINE AND OXYTOCIN BUT NOT BY ACTH IN RATS [J].

ARGIOLAS, A ;

MELIS, MR ;

MAURI, A ;

GESSA, GL .

BRAIN RESEARCH, 1987, 421 (1-2) :349-352

[2] OMEGA-CONOTOXIN PREVENTS APOMORPHINE-INDUCED AND OXYTOCIN-INDUCED PENILE ERECTION AND YAWNING IN MALE-RATS [J].

ARGIOLAS, A ;

MELIS, MR ;

STANCAMPIANO, R ;

GESSA, GL .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1990, 37 (02) :253-257

[3] ROLE OF CALCIUM IN THE EXPRESSION OF ACTH-INDUCED STRETCHING, YAWNING AND PENILE ERECTION [J].

ARGIOLAS, A ;

MELIS, MR ;

STANCAMPIANO, R ;

GESSA, GL .

BRAIN RESEARCH BULLETIN, 1990, 24 (06) :853-856

[4]

BANKOWSKI K, 1980, INT J PEPT PROT RES, V16, P382

[5] THE DOPAMINERGIC INNERVATION OF THE SUPRAOPTIC AND PARAVENTRICULAR NUCLEUS - A LIGHT AND ELECTRON MICROSCOPICAL STUDY [J].

BUIJS, RM ;

GEFFARD, M ;

POOL, CW ;

HOORNEMAN, EMD .

BRAIN RESEARCH, 1984, 323 (01) :65-72

[6] ELECTROPHYSIOLOGICAL EVIDENCE FOR FACILITATORY CONTROL OF OXYTOCIN NEURONS BY OXYTOCIN DURING SUCKLING IN THE RAT [J].

FREUNDMERCIER, MJ ;

RICHARD, P .

JOURNAL OF PHYSIOLOGY-LONDON, 1984, 352 (JUL) :447-466

[7] EXCITATORY EFFECTS OF INTRAVENTRICULAR-INJECTIONS OF OXYTOCIN ON THE MILK EJECTION REFLEX IN THE RAT [J].

FREUNDMERCIER, MJ ;

RICHARD, P .

NEUROSCIENCE LETTERS, 1981, 23 (02) :193-198

[8] EFFECTS OF LESIONS IN THE HYPOTHALAMIC PARAVENTRICULAR, SUPRAOPTIC AND SUPRACHIASMATIC NUCLEI ON VASOPRESSIN AND OXYTOCIN IN RAT-BRAIN AND SPINAL-CORD [J].

HAWTHORN, J ;

ANG, VTY ;

JENKINS, JS .

BRAIN RESEARCH, 1985, 346 (01) :51-57

[9] ASSOCIATION OF SPONTANEOUS AND DOPAMINERGIC-INDUCED YAWNING AND PENILE ERECTIONS IN THE RAT [J].

HOLMGREN, B ;

URBAHOLMGREN, R ;

TRUCIOS, N ;

ZERMENO, M ;

EGUIBAR, JR .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1985, 22 (01) :31-35

[10] EFFECTS OF LESIONS IN THE PARAVENTRICULAR NUCLEUS OF THE HYPOTHALAMUS ON VASOPRESSIN AND OXYTOCIN CONTENTS IN BRAIN-STEM AND SPINAL-CORD OF RAT [J].

LANG, RE ;

HEIL, J ;

GANTEN, D ;

HERMANN, K ;

RASCHER, W ;

UNGER, T .

BRAIN RESEARCH, 1983, 260 (02) :326-329

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