BLOOD LEVODOPA LEVELS AND UNIFIED PARKINSONS-DISEASE RATING-SCALE FUNCTION - WITH AND WITHOUT EXERCISE

被引：28

作者：

GOETZ, CG ^{[1
]}

THELEN, JA ^{[1
]}

MACLEOD, CM ^{[1
]}

CARVEY, PM ^{[1
]}

BARTLEY, EA ^{[1
]}

STEBBINS, GT ^{[1
]}

机构：

[1] RUSH PRESBYTERIAN ST LUKES MED CTR,DEPT PHARMACOL,CHICAGO,IL 60612

来源：

NEUROLOGY | 1993年 / 43卷 / 05期

关键词：

D O I：

10.1212/WNL.43.5.1040

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We studied 10 regular exercising men with Parkinson's disease on levodopa (LD) under two conditions-no exercise and vigorous exercise started 1 hour after LD ingestion. We compared LD levels and motor scores on the Unified Parkinson's Disease Rating Scale (UPDRS). There was a high degree of agreement between plasma LD level and the patients' UPDRS scores 30 minutes later (mean Eta2 = 0.84) in both conditions, with no difference between the two. We conclude that LD levels accurately reflect UPDRS motor function in these patients, and that vigorous exercise started 1 hour after LD ingestion does not influence LD or motor scores.

引用

页码：1040 / 1042

页数：3

共 10 条

[1]

CARTER J H, 1989, Neurology, V39, P320

[2] DOPAMINE SULFATE IN VENTRICULAR CEREBROSPINAL-FLUID AND MOTOR FUNCTION IN PARKINSONS-DISEASE [J].

CEDARBAUM, JM ;

OLANOW, CW .

NEUROLOGY, 1991, 41 (10) :1567-1570

[3]

Fahn S, 1987, RECENT DEV PARKINSON, V2

[4] CONTROLLED-RELEASE CARBIDOPA LEVODOPA (CR4-SINEMET) IN PARKINSONS-DISEASE PATIENTS WITH AND WITHOUT MOTOR FLUCTUATIONS [J].

GOETZ, CG ;

TANNER, CM ;

SHANNON, KM ;

CARROLL, VS ;

KLAWANS, HL ;

CARVEY, PM ;

GILLEY, D .

NEUROLOGY, 1988, 38 (07) :1143-1146

[5] EXERCISE AND THE ANTIPARKINSONIAN RESPONSE TO LEVODOPA [J].

MOURADIAN, MM ;

JUNCOS, JL ;

SERRATI, C ;

FABBRINI, G ;

PALMERI, S ;

CHASE, TN .

CLINICAL NEUROPHARMACOLOGY, 1987, 10 (04) :351-355

[6] LEVODOPA PHARMACOKINETICS AND PHARMACODYNAMICS IN FLUCTUATING PARKINSONIAN-PATIENTS [J].

NUTT, JG ;

WOODWARD, WR .

NEUROLOGY, 1986, 36 (06) :739-744

[7] THE ON OFF PHENOMENON IN PARKINSONS-DISEASE - RELATION TO LEVODOPA ABSORPTION AND TRANSPORT [J].

NUTT, JG ;

WOODWARD, WR ;

HAMMERSTAD, JP ;

CARTER, JH ;

ANDERSON, JL .

NEW ENGLAND JOURNAL OF MEDICINE, 1984, 310 (08) :483-488

[8] L-DOPA TREATMENT FAILURE - EXPLANATION AND CORRECTION [J].

RIVERACA.L ;

DUJOVNE, CA ;

MORGAN, JP ;

LASAGNA, L ;

BIANCHIN.JR .

BRITISH MEDICAL JOURNAL, 1970, 4 (5727) :93-&

[9]

Weber KT, 1986, CARDIOPULMONARY EXER

[10]

1991, GUIDELINES EXERCISE

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