Cytocidal infection of hog cholera virus in porcine bone marrow stroma cell cultures

被引：9
作者：
Shimizu, M
Yamada, S
Nishimori, T
机构：
[1] National Institute of Animal Health, Tsukuba, Ibaraki, 305
来源：
VETERINARY MICROBIOLOGY | 1995年 / 47卷 / 3-4期
关键词：
hog cholera; swine fever; cytopathic effect; bone marrow;
D O I：
10.1016/0378-1135(95)00110-7
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Porcine bone marrow stroma cell (BMSC) cultures producing cells of granulocyte-lineage were established. Hog cholera (HC) virus ALD and Alfort strains replicated in the porcine BMSC cultures showing distinct cytopathic effect (CPE). The differentiation of granulocyte-lineage cells in the cultures ceased after infection with HC virus. Polyclonal antibody against the ALD strain inhibited completely the development of CPE of the both ALD and Alfort strains. Monoclonal antibodies (mAbs) specific to the ALD strain inhibited CPE of the ALD strain, while CPE of the Alfort strain was not affected by those mAbs, suggesting that CPE induced in the BMSC cultures is due to HC virus.
引用
收藏
页码：395 / 400
页数：6
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