PREPARATION OF 2-O-(3-O-CARBAMOYL-ALPHA-D-MANNOPYRANOSYL)-L-GULOPYRANOSE - SYNTHETIC STUDY ON THE SUGAR MOIETY OF ANTITUMOR ANTIBIOTIC BLEOMYCIN

被引:11
|
作者
OSHITARI, T [1 ]
KOBAYASHI, S [1 ]
机构
[1] SAGAMI CHEM RES CTR,SAGAMIHARA,KANAGAWA 229,JAPAN
关键词
D O I
10.1016/0040-4039(94)02458-N
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A new practical route to the disaccharide moiety of bleomycin was developed. Both of key building blocks 9 and 16 were prepared from D-mannose in a regioselective manner by applying stannylene acetal methodology. Glycosylation of the allyl alcohol 9 with the trichloroacetimidate 16 proceeded smoothly, and the further incorporation to the disaccharide moiety was successfully accomplished.
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页码:1089 / 1092
页数:4
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