SYNTHESIS AND CHARACTERIZATION OF OLIGODEOXYNUCLEOTIDES CONTAINING N-(DEOXYGUANOSIN-8-YL)-1-AMINOPYRENE

被引：25

作者：

VYAS, RR ^{[1
]}

NOLAN, SJ ^{[1
]}

BASU, AK ^{[1
]}

机构：

[1] UNIV CONNECTICUT,DEPT CHEM,STORRS,CT 06269

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 14期

关键词：

D O I：

10.1016/S0040-4039(00)77585-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oligodeoxynucleotides containing N-(deoxyguanosin-8-yl)-1-aminopyrene, the major DNA adduct formed by 1-nitropyrene in vivo, were synthesized in 10-20% yield by reacting N-hydroxy-1-aminopyrene with unmodified oligodeoxynucleotides in aqueous DMF. A remarkable feature of this straightforward synthesis is that the covalent adduction was primarily dependent on the existence of double stranded form of the oligonucleotides.

引用

页码：2247 / 2250

页数：4

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