THE NEUROPEPTIDE SUBSTANCE-P STIMULATES PRODUCTION OF INTERLEUKIN-1 IN HUMAN BLOOD MONOCYTES - ACTIVATED CELLS ARE PREFERENTIALLY INFLUENCED BY THE NEUROPEPTIDE

被引:141
作者
LAURENZI, MA
PERSSON, MAA
DALSGAARD, CJ
HAEGERSTRAND, A
机构
[1] KAROLINSKA INST,DEPT ANAT,S-10401 STOCKHOLM 60,SWEDEN
[2] SCRIPPS CLIN & RES FDN,RES INST,DEPT MOLEC BIOL,LA JOLLA,CA 92037
关键词
D O I
10.1111/j.1365-3083.1990.tb02801.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Substance P (SP) has recently been reported to induce interleukin 1 (IL‐1) production by human monocytes. This was confirmed in our experiments with human monocytes cultivated in the presence of SP or SP together with lipopolysaccharide (LPS). In addition, a wide variability of cell response to the neuropeptide was noticed. Three out of twelve cell cultures were directly stimulated by SP to release IL‐1, while four additional cultures needed prestimulation with suboptimal doses of LPS, and no effect was seen in the five remaining experiments. The data may suggest that preferentially activated monocytes respond to SP. The production of IL‐1 by SPstimulated monocytes is of great interest considering the broad spectrum of activity of IL‐1 and the increasing evidence of sensory neuron involvement in acute and chronic inflammatory responses. Copyright © 1990, Wiley Blackwell. All rights reserved
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页码:529 / 533
页数:5
相关论文
共 31 条
[1]   ENHANCEMENT OF PHAGOCYTOSIS - A NEWLY FOUND ACTIVITY OF SUBSTANCE-P RESIDING IN ITS N-TERMINAL TETRAPEPTIDE SEQUENCE [J].
BARSHAVIT, Z ;
GOLDMAN, R ;
STABINSKY, Y ;
GOTTLIEB, P ;
FRIDKIN, M ;
TEICHBERG, VI ;
BLUMBERG, S .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1980, 94 (04) :1445-1451
[2]   INTERLEUKIN-1 ACTS ON CULTURED HUMAN VASCULAR ENDOTHELIUM TO INCREASE THE ADHESION OF POLYMORPHONUCLEAR LEUKOCYTES, MONOCYTES, AND RELATED LEUKOCYTE CELL-LINES [J].
BEVILACQUA, MP ;
POBER, JS ;
WHEELER, ME ;
COTRAN, RS ;
GIMBRONE, MA .
JOURNAL OF CLINICAL INVESTIGATION, 1985, 76 (05) :2003-2011
[4]  
BOYUM A, 1968, SCAND J CLIN LAB INV, VS 21, P77
[5]  
BREARD J, 1980, J IMMUNOL, V124, P1943
[6]  
COZENS PJ, 1987, IMMUNOBIOLOGY, V175, P7
[7]   EFFECTS OF CAPSAICIN PRETREATMENT ON THE INFLAMMATORY RESPONSE TO SCALDING INJURY IN THE RAT [J].
HAEGERSTRAND, A ;
DALSGAARD, CJ ;
JONSSON, CE .
ACTA PHYSIOLOGICA SCANDINAVICA, 1987, 130 (02) :345-348
[8]   ACTIVATION OF MACROPHAGES BY SUBSTANCE-P - INDUCTION OF OXIDATIVE BURST AND THROMBOXANE RELEASE [J].
HARTUNG, HP ;
TOYKA, KV .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1983, 89 (3-4) :301-305
[9]  
HARTUNG HP, 1986, J IMMUNOL, V136, P3856
[10]   SUBSTANCE-P AND ASTROCYTES - STIMULATION OF THE CYCLOOXYGENASE PATHWAY OF ARACHIDONIC-ACID METABOLISM [J].
HARTUNG, HP ;
HEININGER, K ;
SCHAFER, B ;
TOYKA, KV .
FASEB JOURNAL, 1988, 2 (01) :48-51