NOVELTY-INDUCED INCREASE IN DOPAMINE RELEASE IN THE RAT PREFRONTAL CORTEX IN-VIVO - INHIBITION BY DIAZEPAM

被引：128

作者：

FEENSTRA, MGP

BOTTERBLOM, MHA

VANUUM, JFM

机构：

[1] Netherlands Institute for Brain Research, Graduate School Neurosciences Amsterdam, 1105 AZ Amsterdam ZO

来源：

NEUROSCIENCE LETTERS | 1995年 / 189卷 / 02期

关键词：

PREFRONTAL CORTEX; MICRODIALYSIS; DOPAMINE RELEASE; NOVELTY; AROUSAL; STRESS; DIAZEPAM;

D O I：

10.1016/0304-3940(95)11456-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of graded stressful conditions on extracellular concentrations of dopamine (DA) in the medial prefrontal cortex of rats were measured in vivo using microdialysis. Picking up the rat twice with a 20-min interval increased extracellular DA to 120%, exposure to a novel environment by placement in a clean cage for 20 min to 150% and holding the rat in the hands for 20 min to over 200%. Diazepam (5 mg/kg) decreased DA to about 75% and attenuated the novelty- and handling-induced increases. Exposure to novelty or handling are easy and simple methods to obtain graded increases of in vivo cortical DA release.

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页码：81 / 84

页数：4

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