THIA-PROSTANOID ANALOGS WITH COMBINED THROMBOXANE RECEPTOR ANTAGONIST THROMBOXANE SYNTHASE INHIBITOR ACTIVITIES - SYNTHESIS AND PHARMACOLOGICAL EVALUATION

被引：5
|
作者：
VLATTAS, I
DELLUREFICIO, J
COHEN, DS
LEE, W
CLARKE, F
DOTSON, R
MATHIS, J
ZOGANAS, H
机构：
[1] Research Department, Pharmaceuticals Division, Ciba-Geigy Corporation, Summit, NJ 07901
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 17期
关键词：
D O I：
10.1016/S0960-894X(01)80103-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
This report describes the incorporation of thia-prostanoid, amino-prostanoid and thromboxane synthase inhibitor features into a new series of thia-prostanoids that combines potent thromboxane receptor antagonist/thromboxane synthase inhibitor activities. Synthesis and biological evaluation is discussed.
引用
收藏
页码：2067 / 2072
页数：6
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