PRODUCTION OF TRANSFORMING GROWTH FACTOR-ALPHA BY HAMSTER EOSINOPHILS

被引：0

作者：

ELOVIC, A

GALLI, SJ

WELLER, PF

CHANG, ALC

TAO, C

MING, YC

DONOFF, RB

GALLAGHER, GT

MATOSSIAN, K

MCBRIDE, J

TSAI, M

TODD, R

WONG, DTW

机构：

[1] HARVARD UNIV,SCH DENT MED,DEPT ORAL MED & ORAL PATHOL,188 LONGWOOD AVE,BOSTON,MA 02115

[2] HARVARD UNIV,SCH DENT MED,DEPT ORAL & MAXILLOFACIAL SURG,BOSTON,MA 02115

[3] BETH ISRAEL HOSP,DEPT PATHOL,BOSTON,MA 02215

[4] BETH ISRAEL HOSP,DEPT MED,BOSTON,MA 02215

[5] HARVARD UNIV,SCH MED,BOSTON,MA 02115

[6] BETH ISRAEL HOSP,CHARLES A DANA RES INST,BOSTON,MA 02215

来源：

AMERICAN JOURNAL OF PATHOLOGY | 1990年 / 137卷 / 06期

关键词：

D O I：

暂无

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Previously it was demonstrated that malignant transformation of the Syrian hamster cheek pouch mucosa is associated with the expression of TGF-alpha. Therefore in situ hybridization and immunohistochemistry was used to investigate the cellular sources of TGF-alpha production in this model system. Surprisingly one cell type in the inflammatory infiltrate present in the connective tissue adjacent to the transformed epithelium represented a major source of TGF-alpha mRNA. Detailed analysis of these cells revealed that they were eosinophils. In addition to TGF-alpha mRNA, about 40% of the eosinophils associated with the oral tumors exhibited TGF-alpha product reactive with a monoclonal antibody against the C terminus of the mature TGF-alpha peptide. Normal hamster bone marrow eosinophils also exhibited TGF-alpha mRNA and product by in situ hybridization and immunohistochemistry. These results suggest that the eosinophil represents a biologically significant source of TGF-alpha.

引用

页码：1425 / 1434

页数：10