PRODUCTION OF TRANSFORMING GROWTH FACTOR-ALPHA BY HAMSTER EOSINOPHILS

被引:0
作者
ELOVIC, A
GALLI, SJ
WELLER, PF
CHANG, ALC
TAO, C
MING, YC
DONOFF, RB
GALLAGHER, GT
MATOSSIAN, K
MCBRIDE, J
TSAI, M
TODD, R
WONG, DTW
机构
[1] HARVARD UNIV,SCH DENT MED,DEPT ORAL MED & ORAL PATHOL,188 LONGWOOD AVE,BOSTON,MA 02115
[2] HARVARD UNIV,SCH DENT MED,DEPT ORAL & MAXILLOFACIAL SURG,BOSTON,MA 02115
[3] BETH ISRAEL HOSP,DEPT PATHOL,BOSTON,MA 02215
[4] BETH ISRAEL HOSP,DEPT MED,BOSTON,MA 02215
[5] HARVARD UNIV,SCH MED,BOSTON,MA 02115
[6] BETH ISRAEL HOSP,CHARLES A DANA RES INST,BOSTON,MA 02215
关键词
D O I
暂无
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Previously it was demonstrated that malignant transformation of the Syrian hamster cheek pouch mucosa is associated with the expression of TGF-alpha. Therefore in situ hybridization and immunohistochemistry was used to investigate the cellular sources of TGF-alpha production in this model system. Surprisingly one cell type in the inflammatory infiltrate present in the connective tissue adjacent to the transformed epithelium represented a major source of TGF-alpha mRNA. Detailed analysis of these cells revealed that they were eosinophils. In addition to TGF-alpha mRNA, about 40% of the eosinophils associated with the oral tumors exhibited TGF-alpha product reactive with a monoclonal antibody against the C terminus of the mature TGF-alpha peptide. Normal hamster bone marrow eosinophils also exhibited TGF-alpha mRNA and product by in situ hybridization and immunohistochemistry. These results suggest that the eosinophil represents a biologically significant source of TGF-alpha.
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收藏
页码:1425 / 1434
页数:10
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