Fine mapping of the hyperglycemic and obesity QTL by congenic strains suggests multiple loci on rat chromosome

被引：9

作者：

Akhi, Masuda ^{[1
]}

Kose, Hiroyuki ^{[1
]}

Matsumoto, Kozo ^{[1
]}

机构：

[1] Univ Tokushima, Grad Sch, Inst Hlth Biosci, Div Anim Res Resources, Tokushima, Japan

来源：

JOURNAL OF MEDICAL INVESTIGATION | 2005年 / 52卷 / 1-2期

关键词：

QTL; congenic strain; OLETF; type; 2; diabetes;

D O I：

10.2152/jmi.52.109

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Linkage analysis previously identified ahyperglycemic quantitative trait locus (QTL), Nidd 2/of, on rat Chromosome 14 in crosses utilizing OLETF (Otsuka Long Evans Tokushima Fatty) rat, a model for type 2 diabetes. A separate QTL study mapped an obesity QTL, Obs5, to the same chromosomal region. A congenic strain placing ca. 38cMOLETF-derived segments containing both Nidd2/of and Obs5 on the F344 background was shown to possess mild diabetic and obese phenotypes, suggesting the presence of mutations affecting the glucose metabolism and fat accumulation. In order to localize the loci more precisely, we generated a series of deletion subcongenic strains in which OLETF-segments were shortened from either ends. We found that there are at least two hyperglycemic QTLs with in the Nidd2/of locus. We predict that they are localized towards both ends of the Nidd2/of region. In contrast, Obs5QTL was further narrowed down to a single region of ca. 10 cM fragment.

引用

页码：109 / 113

页数：5

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