ACTIVATION OF BASAL FOREBRAIN CHOLINERGIC NEURONS DIFFERENTIALLY REGULATES BRAIN-DERIVED NEUROTROPHIC FACTOR MESSENGER-RNA EXPRESSION IN DIFFERENT PROJECTION AREAS

被引：24
作者：
BOATELL, LL
LINDEFORS, N
BALLARIN, M
ERNFORS, P
MAHY, N
PERSSON, H
机构：
[1] KAROLINSKA INST,DEPT MED CHEM,MOLEC NEUROBIOL LAB,S-10401 STOCKHOLM 60,SWEDEN
[2] UNIV BARCELONA MED,FAC MED,UNIDAD BIOQUIM,BARCELONA,SPAIN
来源：
NEUROSCIENCE LETTERS | 1992年 / 136卷 / 02期
关键词：
NGF FAMILY OF NEUROTROPHIC FACTORS; INSITU HYBRIDIZATION; SYNAPTIC ACTIVATION; QUISQUALATE; MUSCIMOL;
D O I：
10.1016/0304-3940(92)90049-D
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Afferent cholinergic pathways from the basal forebrain were activated by injections of the glutamate analog quisqualate either into the nucleus basalis or into the medial septal nucleus. Nucleus basalis injections had no effect on the expression of brain-derived neurotrophic factor (BDNF) mRNA in its neocortical projection areas as measured by in situ hybridization. In contrast, 7 h after an injection into the septum the level of BDNF mRNA increased 3- to 5-fold in the dentate gyrus, throughout CA1 to CA3 in the hippocampus and in the piriform cortex.
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页码：203 / 208
页数：6
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