5-HT RECEPTOR-MEDIATED REGULATION OF THYROTROPIN-RELEASING-HORMONE RELEASE IN RAT SPINAL-CORD

被引：0

作者：

ONO, H ^{[1
]}

ONO, SS ^{[1
]}

FUKUDA, H ^{[1
]}

机构：

[1] NIHON UNIV,COLL PHARM,DEPT PHARMACOL,CHIBA 274,JAPAN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 203卷 / 02期

关键词：

5-HT; (5-HYDROXYTRYPTAMINE; SEROTONIN); THYROTROPIN-RELEASING HORMONE (TRH) RELEASE; SPINAL CORD;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

5-Hydroxytryptamine (5-HT, 10-mu-M) increased the veratridine-evoked release of thyrotropin-releasing hormone (TRH) from spinal cord slices. This effect of 5-HT was reduced by pre-exposure of the tissue to 10-mu-M ketanserin and methysergide, which both have 5-HT2 antagonistic activity. A 5-HT1 agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (10-mu-M), reduced the release of TRH. These results imply that 5-HT released from the terminals of descending fibers modulates the release of TRH, a cotransmitter contained in 5-HT fibers.

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页码：283 / 285

页数：3

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