INSITU HYBRIDIZATION OF 2 MARKERS CLOSELY FLANKING THE SPINAL MUSCULAR-ATROPHY GENE TO 5Q12-]Q13.3

被引：4

作者：

MATTEI, MG

MELKI, J

BACHELOT, MF

ABDELHAK, S

BURLET, P

FREZAL, J

MUNNICH, A

机构：

[1] HOP NECKER ENFANTS MALAD,INSERM,U 12,UNITE RECH HANDICAPS GENET ENFANT,149 RUE SEVRES,F-75743 PARIS 15,FRANCE

[2] HOP LA TIMONE,INSERM,U 242,UNITE RECH PHYSIOPATHOL CHROMOSOM,MARSEILLE,FRANCE

来源：

CYTOGENETICS AND CELL GENETICS | 1991年 / 57卷 / 2-3期

关键词：

D O I：

10.1159/000133125

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In order to refine the physical location of the p105-153Ra and M4 probes which closely flank the spinal muscular atrophy gene (SMA) on human chromosome 5q, in situ hybridization has been carried out on prometaphase chromosomes. Our results demonstrate that the disease gene is located between the 5q12 --> q13.1 and 5q13.3 bands. The present study will hopefully contribute to microdissection of the chromosomal region of the SMA gene.

引用

页码：112 / 113

页数：2

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