PHOSPHORYLATION OF THE NICOTINIC ACETYLCHOLINE-RECEPTOR REGULATES ITS RATE OF DESENSITIZATION

被引：384
作者：
HUGANIR, RL [1 ]
DELCOUR, AH [1 ]
GREENGARD, P [1 ]
HESS, GP [1 ]
机构：
[1] CORNELL UNIV,BIOCHEM MOLEC & CELL BIOL SECT,ITHACA,NY 14853
来源：
NATURE | 1986年 / 321卷 / 6072期
关键词：
D O I：
10.1038/321774a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
引用
收藏
页码：774 / 776
页数：3
相关论文
共 26 条
[1]   A POSSIBLE INVOLVEMENT OF CYCLIC-AMP IN THE EXPRESSION OF DESENSITIZATION OF THE NICOTINIC ACETYLCHOLINE-RECEPTOR - A STUDY WITH FORSKOLIN AND ITS ANALOGS [J].
ALBUQUERQUE, EX ;
DESHPANDE, SS ;
ARACAVA, Y ;
ALKONDON, M ;
DALY, JW .
FEBS LETTERS, 1986, 199 (01) :113-120
[2]   MECHANISM OF INACTIVATION (DESENSITIZATION) OF ACETYLCHOLINE-RECEPTOR - INVESTIGATIONS BY FAST REACTION TECHNIQUES WITH MEMBRANE-VESICLES [J].
AOSHIMA, H ;
CASH, DJ ;
HESS, GP .
BIOCHEMISTRY, 1981, 20 (12) :3467-3474
[3]   PROTEIN-PHOSPHORYLATION AND NEURONAL FUNCTION [J].
BROWNING, MD ;
HUGANIR, R ;
GREENGARD, P .
JOURNAL OF NEUROCHEMISTRY, 1985, 45 (01) :11-23
[4]   QUENCHED FLOW TECHNIQUE WITH PLASMA-MEMBRANE VESICLES - ACETYLCHOLINE RECEPTOR-MEDIATED TRANSMEMBRANE ION FLUX [J].
CASH, DJ ;
HESS, GP .
ANALYTICAL BIOCHEMISTRY, 1981, 112 (01) :39-51
[5]   ACETYLCHOLINE-RECEPTOR - AN ALLOSTERIC PROTEIN [J].
CHANGEUX, JP ;
DEVILLERSTHIERY, A ;
CHEMOUILLI, P .
SCIENCE, 1984, 225 (4668) :1335-1345
[6]  
CHANGEUX JP, 1983, COLD SPRING HARB S Q, V47
[7]   NUCLEOTIDE AND DEDUCED AMINO-ACID-SEQUENCES OF TORPEDO-CALIFORNICA ACETYLCHOLINE-RECEPTOR GAMMA-SUBUNIT [J].
CLAUDIO, T ;
BALLIVET, M ;
PATRICK, J ;
HEINEMANN, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (04) :1111-1115
[8]   COMPLETE MESSENGER-RNA CODING SEQUENCE OF THE ACETYLCHOLINE BINDING ALPHA-SUBUNIT OF TORPEDO-MARMORATA ACETYLCHOLINE-RECEPTOR - A MODEL FOR THE TRANSMEMBRANE ORGANIZATION OF THE POLYPEPTIDE-CHAIN [J].
DEVILLERSTHIERY, A ;
GIRAUDAT, J ;
BENTABOULET, M ;
CHANGEUX, JP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (07) :2067-2071
[9]   AGENTS THAT ACTIVATE PROTEIN KINASE-C REDUCE ACETYLCHOLINE SENSITIVITY IN CULTURED MYOTUBES [J].
EUSEBI, F ;
MOLINARO, M ;
ZANI, BM .
JOURNAL OF CELL BIOLOGY, 1985, 100 (04) :1339-1342
[10]   AMPHIPATHIC ANALYSIS AND POSSIBLE FORMATION OF THE ION CHANNEL IN AN ACETYLCHOLINE-RECEPTOR [J].
FINERMOORE, J ;
STROUD, RM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (01) :155-159
123