CAFFEINE INHIBITS FORSKOLIN-STIMULATED CYCLIC-AMP ACCUMULATION IN RAT-BRAIN

被引：8

作者：

MANTE, S ^{[1
]}

MINNEMAN, KP ^{[1
]}

机构：

[1] EMORY UNIV,SCH MED,DEPT PHARMACOL,ATLANTA,GA 30322

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 175卷 / 02期

关键词：

(Rat); Caffeine; cAMP; Cortex; Forskolin;

D O I：

10.1016/0014-2999(90)90231-T

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Caffeine potently inhibited forskolin-stimulated cyclic AMP accumulation in slices of rat cerebral cortex. The IC50 for this inhibition was 21 ± 2.9 μM, and 200 μM caffeine almost completely blocked the forskolin response. Theophylline which is a behavioural stimulant mimicked the effect of caffeine. However, there was only a slight inhibition of the forskolin response by theobromine and IBMX (3-isobutyl-1-methylxanthine), both of which lack behavioral stimulant effects. © 1990.

引用

页码：203 / 205

页数：3

共 10 条

[1]

BAZIL CW, 1986, J NEUROCHEM, V47, P547

[2]

BEAVO JA, 1970, MOL PHARMACOL, V6, P597

[3] CALCIUM RELEASE FROM SARCOPLASMIC-RETICULUM [J].