Progression of Monoclonal Gammopathy with Undetermined Significance to Multiple Myeloma Diagnosed by Kidney Biopsy: A Case Report

被引：2

作者：

Kim, Jin Hae ^{[1
]}

Kim, Ji Won ^{[1
]}

Kim, Young Nam ^{[1
]}

Kim, Hye In ^{[1
]}

Kim, Jun Young ^{[1
]}

Kwon, Ghee Young ^{[3
]}

Kim, Kihyun ^{[4
]}

Jang, Hye Ryoun ^{[2
]}

机构：

[1] Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Med, Seoul, South Korea

[2] Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Med,Div Nephrol, 81 Irwon Ro, Seoul 135710, South Korea

[3] Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Pathol, Seoul, South Korea

[4] Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Med,Div Hematol Oncol, Seoul, South Korea

来源：

CASE REPORTS IN NEPHROLOGY AND DIALYSIS | 2015年 / 5卷 / 03期

关键词：

Multiple myeloma; Monoclonal gammopathy of undetermined significance; Proteinuria;

D O I：

10.1159/000439267

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Monoclonal gammopathy with undetermined significance (MGUS) carries a risk of progression to multiple myeloma, and progression is usually diagnosed with changes in M-protein or bone marrow biopsy. We report a case of 62-year-old female patient showing MGUS progression to multiple myeloma without significant changes in M-protein but diagnosed by kidney biopsy. During the follow-ups, azotemia and tubular proteinuria were aggravated without elevation of M-protein. Kidney biopsy showed intratubular and glomerular inclusions associated with plasma cell dysplasia. The progression of MGUS to multiple myeloma was diagnosed by this kidney biopsy. The patient's renal function and tubular proteinuria were markedly improved after chemotherapy. (C) 2015 S. Karger AG, Basel

引用

页码：180 / 186

页数：7

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