A TOTAL SYNTHESIS OF ARENASTATIN-A, AN EXTREMELY POTENT CYTOTOXIC DEPSIPEPTIDE, FROM THE OKINAWAN MARINE SPONGE DYSIDEA-ARENARIA

被引：0

作者：

KOBAYASHI, M ^{[1
]}

KUROSU, M ^{[1
]}

WANG, WQ ^{[1
]}

KITAGAWA, I ^{[1
]}

机构：

[1] OSAKA UNIV, FAC PHARMACEUT SCI, SUITA, OSAKA 565, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1994年 / 42卷 / 11期

关键词：

MARINE SPONGE; DYSIDEA ARENARIA; DEPSIPEPTIDE; ARENASTATIN A; CYTOTOXIC;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An asymmetric synthesis of a cyclic depsipeptide arenastatin A (1), which was isolated from the marine sponge Dysidea arenaria and exhibited extremely potent cytotoxicity with IC50 5 pg/ml for KB cells, has been accomplished.

引用

页码：2394 / 2396

页数：3

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