Tumor markers in the diagnosis, monitoring and therapy of pancreatic cancer: State of the art

被引：24

作者：

Plebani, M ^{[1
]}

Basso, D ^{[1
]}

Panozzo, MP ^{[1
]}

Fogar, P ^{[1
]}

DelFavero, G ^{[1
]}

Naccarato, R ^{[1
]}

机构：

[1] UNIV PADUA, DEPT GASTROENTEROL, I-35100 PADUA, ITALY

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS | 1995年 / 10卷 / 04期

关键词：

monoclonal antibodies; MIA PaCa 2 pancreatic cell line; pancreatic cancer; CA; 19-9;

D O I：

10.1177/172460089501000401

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The present review focuses on the utility of serum tumor markers in screening, diagnosis, prognosis and monitoring of pancreatic cancer: Serum determination of all tumor markers studied offers no help in screening or ear-ly diagnosis of pancreatic cancer. For diagnosis, blood group-related antigens, in particular CA 19-9, are consider-ed the best indicators of this neoplasm. However, as occurs with other glycoproteic tumor markers, the circulating levels of CA 19-9 are significantly influenced by jaundice, probably because its liver metabolism is reduced. Therefore, the finding of elevated CA 19-9 levels in jaundiced patients has to be evaluated with caution. Since pancreatic cancer recurrences ale not susceptible to treatment, the clinical role of widespread use of tumor marker determination in follow-up programs is limited and calls for a critical evaluation.

引用

页码：189 / 199

页数：11

共 105 条

[1] AN IMMUNOHISTOLOGIC STUDY OF THE FETO-ACINAR PANCREATIC PROTEIN (FAP) IN THE NORMAL PANCREAS, CHRONIC-PANCREATITIS, PANCREATIC ADENOCARCINOMA, AND INTRAABDOMINAL METASTASES OF ADENOCARCINOMAS [J].