REGION DISTRIBUTION OF THE GANGLIOSIDES IN RAT-BRAIN AFTER CHRONIC ETHANOL TREATMENT

被引：3

作者：

VRBASKI, SR

机构：

来源：

MOLECULAR AND CHEMICAL NEUROPATHOLOGY | 1995年 / 25卷 / 2-3期

关键词：

ETHANOL; GANGLIOSIDES; CAUDATE NUCLEUS; CEREBRAL CORTEX; HYPOTHALAMUS; THALAMUS; HIPPOCAMPUS;

D O I：

10.1007/BF02960920

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In this study the effects of chronic ethanol administration on the regional distribution of brain gangliosides were investigated. A total of 36 60-d-old male Wistar rats weighing approximately 200 g was divided into two groups of 18 animals each. The ethanol-consuming group was offered drinking fluid (25% sucrose-32% ethyl alcohol, w/w) ad libitum, and the control group was given a sucrose solution isocaloric with the ethanol-sucrose solution. After 6 mo of chronic ethanol treatment, cerebral cortex, N. caudatus, hypothalamus, thalamus, and hippocampus were analyzed with respect to their ganglioside pattern (G(M2), G(M1), G(D1a), G(D1b), G(T1b), and G(Q)). The results showed that there were highly significant effects of ethanol on hypothalamus G(D1b) and G(T1b), thalamus G(M1) and G(D1a), and hippocampus G(M1), G(D1b), and G(T1b) ganglioside distribution. It was found that ethanol differently affected the gangliosides in these brain regions.

引用

页码：273 / 281

页数：9

共 30 条

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