DIFFERENTIAL EXPRESSION OF GENES ENCODING TGFS BETA-1, BETA-2, AND BETA-3 DURING MURINE PALATE FORMATION

Transforming growth factor β1 (TGFβ1) has been shown to have multiple effects on primary cultures of palate-derived cell types. We report the analysis, by in situ hybridization, of RNA expression for three different TGFβ isoforms (TGFβ1, β2, and β3) during murine embryonic palate development. Differential expression of the three TGFβ genes is seen in the palatal shelves in mesenchymal and epithelial cells known to be involved in the morphogenesis of this organ. Taken together, these results suggest that the TGFβs act as endogenous factors involved in the formation of the mammalian palate. © 1990.