An alternative way to initiate Notch1 signaling in non-small cell lung cancer

被引：7
|
作者：
Yang, Yi-Lin [1 ]
Jablons, David [1 ]
You, Liang [1 ]
机构：
[1] Univ Calif San Francisco, Comprehens Canc Ctr, Dept Surg, Thorac Oncol Lab, San Francisco, CA 94143 USA
来源：
TRANSLATIONAL LUNG CANCER RESEARCH | 2014年 / 3卷 / 04期
关键词：
Notch signaling; Delta-like ligand 4 (Dll4); non-small cell lung cancer (NSCLC);
D O I：
10.3978/j.issn.2218-6751.2013.12.06
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Non-small cell lung cancer (NSCLC) cells activate Notch1 signaling to promote cell proliferation and facilitate their survival. It now emerges that endothelial Delta-like ligand 4 (Dll4) may mediate Notch1 activation and inhibit tumor cell growth.
引用
收藏
页码：238 / 241
页数：4
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