Inter-company consent document ANMCO / ANCE / ARCA / GICR-IACPR / GISE / SICOA: Long-term antiplatelet therapy in patients with coronary artery disease

被引：3

作者：

Gulizia, Michele Massimo ^{[1
]}

Colivicchi, Furio ^{[2
]}

Abrignani, Maurizio Giuseppe ^{[3
]}

Ambrosetti, Marco ^{[4
]}

Aspromonte, Nadia ^{[5
]}

Barile, Gabriella ^{[6
]}

Caporale, Roberto ^{[7
]}

Casolo, Giancarlo ^{[8
]}

Chiuini, Emilia ^{[9
]}

Di Lenarda, Andrea ^{[10
]}

Faggiano, Pompilio ^{[11
]}

Gabrielli, Domenico ^{[12
]}

Geraci, Giovanna ^{[13
]}

La Manna, Alessio Gaetano ^{[14
]}

Maggioni, Aldo Pietro ^{[15
]}

Marchese, Alfredo ^{[16
]}

Massari, Ferdinando Maria ^{[17
]}

Mureddul, Gian Francesco ^{[18
]}

Musumeci, Giuseppe ^{[19
]}

Nardi, Federico ^{[20
]}

Panno, Antonio Vittorio ^{[21
]}

Pedretti, Roberto Franco Enrico ^{[22
]}

Piredda, Massimo ^{[23
]}

Pusineri, Enrico ^{[24
]}

Riccio, Carmine ^{[25
]}

Rossini, Roberta ^{[19
]}

di Uccio, Fortunato Scotto ^{[26
]}

Urbinati, Stefano ^{[27
]}

Varbella, Ferdinando ^{[28
]}

Zito, Giovanni Battista ^{[29
]}

De Luca, Leonardo ^{[30
]}

机构：

[1] Osped Garibaldi Nesima, Azienda Rilievo Nazl & Alta Specializzaz Garibald, UOC Cardiol, Via Palermo 636, I-95122 Catania, Italy

[2] Presidio Osped San Filippo Neri, UOC Cardiol & UTIC, Rome, Italy

[3] Osped Civile St Antonio Abate, UOC Cardiol & UTIC, Erice, TP, Italy

[4] Clin Terrazze, Serv Cardiol Riabilitat, Cunardo, VA, Italy

[5] Policlin Agostino Gemelli, Polo Sci Cardiovasc & Toraciche, UO Scompenso & Riabilitaz Cardiol, Rome, Italy

[6] Poliambulatorio ASL RM C D11, Rome, Italy

[7] Osped Annunziata, UOC Cardiol Interventist, Cosenza, Italy

[8] Nuovo Osped Versilia, SC Cardiol, Lido Di Camaiore, LU, Italy

[9] ASL Umbria 1, Specialista Ambulatoriale Cardiol, Perugia, Italy

[10] Azienda Sanitaria Univ Integrata Trieste, SC Cardiovasc & Med Sport, Trieste, Italy

[11] Spedali Civil Brescia, UO Cardiol, Brescia, Italy

[12] Osped Civile Augusto Murri, ASUR Marche, Area Vasta Fermo 4, Fermo, Italy

[13] Azienda Osped Riuniti Villa Sofia Cervello, UOC Cardiol, Palermo, Italy

[14] AOU Policlin Vittorio Emanuele, Div Cardiol, Catania, Italy

[15] Fdn Tuo Cuore, Ctr ANMCO, Florence, Italy

[16] GVM Care & Res Osped Santa Maria, UOC Cardiol Interventist, Bari, Italy

[17] Osped Maggiore Policlin, Fdn IRCCS Ca Granda, UOC Malattie Cardiovasc, Milan, Italy

[18] AO San Giovanni Addolorata, UOC Cardiol 2, Rome, Italy

[19] ASO Santa Croce e Carle, SC Cardiol, Cuneo, Italy

[20] Osped Santo Spirito, SC Cardiol, Casale Monferrato, AL, Italy

[21] Convenz USL 6, Palermo, Italy

[22] IRCCS, Ist Clin Sci Maugeri, Dipartirnento Cardiol Riabilitat, Pavia, Italy

[23] Ist Clin St Ambrogio, Ctr Cardiotorac, Div Cardiol, Milan, Italy

[24] Osped Civile Vigevano, ASST, UOC Cardiol, Pavia, Italy

[25] AO St Anna & San Sebastiano, Prevenz & Riahilitaz Cardiopat, Caserta, Italy

[26] Osped Loreto Mare, UO Cardiol & UTIC, ASL NA 1, Naples, Italy

[27] Osped Bellaria, AUSL Bologna, UOC Cardiol, Bologna, Italy

[28] Osped Riuniti Rivoli, SC Cardiol, Rivoli, TO, Italy

[29] ASL Napoli 3 Sud, Ambulatorio Cardiol, Pompei, NA, Italy

[30] Osped San Giovanni Evangelista, UOC Cardiol, Tivoli, RM, Italy

来源：

GIORNALE ITALIANO DI CARDIOLOGIA | 2018年 / 19卷 / 05期

关键词：

Coronary artery disease; Dual anti platelet therapy; Long-term dual anti platelet therapy; Prior myocardial infarction;

D O I：

10.1714/2907.29280

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Dual antiplatelet therapy (DAPT) with aspirin and a P2Y(12) receptor inhibitor is the cornerstone of the pharmacologic management of patients with acute coronary syndrome (ACS) and/or receiving coronary stents. Long-term (>1 year) DAPT may further reduce the risk of stent thrombosis after percutaneous coronary intervention (PCI) and may decrease the occurrence of non-stent-related ischemic events in patients with ACS. Nevertheless, compared with aspirin alone, extended use of aspirin plus a P2Y(12) receptor inhibitor may increase the risk of bleeding events that have been strongly linked to adverse outcomes including recurrent ischemia, repeat hospitalization, and death. Over the last years, multiple randomized clinical trials have been published comparing duration of DART after PCI and in ACS patients investigating either a shorter or prolonged DAPT regimen. Although current European Society of Cardiology guidelines provide backup to individualize treatment, it seems difficult to identify the ideal patient profile who could safely reduce or prolong DAPT duration in daily clinical practice. The aim of this consensus document is to review the contemporary literature on optimal DART duration and to guide clinicians in tailoring antiplatelet strategies in patients undergoing PCI or presenting with ACS.

引用

页码：263 / 331

页数：69

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