Sleep and Anesthesia Common Mechanisms of Action

被引：19
作者：
Vacas, Susana [1 ,2 ]
Kurien, Philip [1 ]
Maze, Mervyn [1 ]
机构：
[1] Univ Calif San Francisco, Dept Anesthesia & Perioperat Care, 521 Parnassus Ave, San Francisco, CA 94143 USA
[2] Programme Adv Med Educ, P-1067 Lisbon, Portugal
来源：
SLEEP MEDICINE CLINICS | 2013年 / 8卷 / 01期
关键词：
Anesthesia; Sleep; Circadian rhythm; Dexmedetomidine;
D O I：
10.1016/j.jsmc.2012.11.009
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Appropriate sleep hygiene is crucial for repair in states of disease and injury and in restoring function especially in the central nervous and immune systems. Anesthetics have different action targets and ultimately different consequences. The effects of anesthetics on circadian rhythm possibly also lead to immune deregulation. alpha 2-adrenergic agonists converge on sleep pathways within the brainstem and are associated with changes in neuronal activity similar to those seen in deeper stages of NREM sleep. Thoughtful attention must be made in selecting an anesthetic agent that best mimics natural sleep. Future studies will further elucidate the benefits of dexmedetomidine as a good anesthetic/sedative candidate.
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页码：1 / +
页数：10
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