The Mushroom Agaricus blazei Murill Elicits Medicinal Effects on Tumor, Infection, Allergy, and Inflammation through Its Modulation of Innate Immunity and Amelioration of Th1/Th2 Imbalance and Inflammation

被引：43
作者：
Hetland, Geir [1 ]
Johnson, Egil [2 ]
Lyberg, Torstein [3 ,4 ]
Kvalheim, Gunnar [1 ]
机构：
[1] Oslo Univ Hosp, Norwegian Radium Hosp, Dept Cellular Therapy, Ullernchaussen 70, N-0130 Oslo, Norway
[2] Oslo Univ Hosp, Ulleval Hosp, Dept Gastroenterol Surg, Oslo, Norway
[3] Univ Oslo, Oslo, Norway
[4] Oslo Univ Hosp, Ulleval Hosp, Ctr Clin Res, Oslo, Norway
来源：
ADVANCES IN PHARMACOLOGICAL SCIENCES | 2011年 / 2011卷
关键词：
D O I：
10.1155/2011/157015
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The medicinal mushroom Agaricus blazeiMurill from the Brazilian rain forest has been used in traditional medicine and as health food for the prevention of a range of diseases, including infection, allergy, and cancer. Other scientists and we have examined whether there is scientific evidence behind such postulations. Agaricus blazeiMis rich in the immunomodulating polysaccharides, beta-glucans, and has been shown to have antitumor, anti-infection, and antiallergic/-asthmatic properties in mouse models, in addition to anti-inflammatory effects in inflammatory bowel disease patients. These effects are mediated through the mushroom's stimulation of innate immune cells, such as monocytes, NK cells, and dendritic cells, and the amelioration of a skewed Th1/Th2 balance and inflammation.
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页数：10
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共 60 条
[1]   The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease [J].
Afzali, B. ;
Lombardi, G. ;
Lechler, R. I. ;
Lord, G. M. .
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2007, 148 (01) :32-46
[2]   Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy [J].
Ahn, WS ;
Kim, DJ ;
Chae, GT ;
Lee, JM ;
Bae, SM ;
Sin, JI ;
Kim, YW ;
Namkoong, SE ;
Lee, IP .
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2004, 14 (04) :589-594
[3]   Cancer and Inflammation: Implications for Pharmacology and Therapeutics [J].
Balkwill, F. ;
Mantovani, A. .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2010, 87 (04) :401-406
[4]   Dendritic cell subtypes as primary targets of vaccines:: the emerging role and cross-talk of pattern recognition receptors [J].
Benko, Szilvia ;
Magyarics, Zoltan ;
Szabo, Attila ;
Rajnavolgyi, Eva .
BIOLOGICAL CHEMISTRY, 2008, 389 (05) :469-485
[5]   An extract of the mushroom Agaricus blazei Murill protects against lethal septicemia in a mouse model of fecal peritonitis [J].
Bernardshaw, S ;
Hetland, G ;
Grinde, B ;
Johnson, E .
SHOCK, 2006, 25 (04) :420-425
[6]   An extract of the mushroom Agaricus blazei Murill administered orally protects against systemic Streptococcus pneumoniae infection in mice [J].
Bernardshaw, S ;
Johnson, E ;
Hetland, G .
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2005, 62 (04) :393-398
[7]   Effect of an extract of the mushroom Agaricus blazei Murill on expression of adhesion molecules and production of reactive oxygen species in monocytes and granulocytes in human whole blood ex vivo [J].
Bernardshaw, Soosaipillai ;
Lyberg, Torstein ;
Hetland, Geir ;
Johnson, Egil .
APMIS, 2007, 115 (06) :719-725
[8]   An extract of the medicinal mushroom Agaricus blazei Murill differentially stimulates production of pro-inflammatory cytokines in human monocytes and human vein endothelial cells in vitro [J].
Bernardshaw, Soosaipillai ;
Hetland, Geir ;
Ellertsen, Linda Kathrine ;
Tryggestad, Anne Merete Aaland ;
Johnson, Egil .
INFLAMMATION, 2005, 29 (4-6) :147-153
[9]   The effects of β-glucan on human immune and cancer cells [J].
Chan, Godfrey Chi-Fung ;
Chan, Wing Keung ;
Sze, Daniel Man-Yuen .
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2009, 2
[10]   Extract from Agaricus blazei Murill can enhance immune responses elicited by DNA vaccine against foot-and-mouth disease [J].
Chen, L ;
Shao, HJ .
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2006, 109 (1-2) :177-182
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