NONHISTONE CHROMOSOMAL-PROTEINS (NHCP) IN ADENOCARCINOMA OF HUMAN ENDOMETRIUM

被引：0
作者：
MITURSKI, R [1 ]
机构：
[1] MED ACAD LUBLIN,GYNAECOL SURG CLIN 2,PL-20950 LUBLIN,POLAND
来源：
ACTA BIOCHIMICA POLONICA | 1995年 / 42卷 / 02期
关键词：
NONHISTONE CHROMOSOMAL PROTEINS; ADENOCARCINOMA; WOMAN;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Concentration and electrophoretic pattern of nonhistone chromosomal proteins (NHCP) in cancer and normal endometrium were examined. In normal tissues the NHCP/DNA ratio ranged from 0.6 to 0.8 whereas in malignant tissues from 1.2 to 1.7. Mean nuclear concentration of NHCP was 14.16 pg/cell nucleus of normal endometrium and 33.35 pg/cell nucleus of cancer tissue. The two tissues differed in the electrophoretic pattern. Heavy fractions (> 60 kDa - 36%) predominated in normal tissue whereas light fractions (< 30 kDa - 48%) in malignant tissue samples. The percentage of intermediate fractions (30-60 kDa) was similar. Neoplastic endometrium shows, irrespective of the patient's age, a high NHCP content. It seems that NHCP, especially the fraction extracted with 0.35 M NaCl, because of its tissue and cell specificity are involved in neoplasm formation.
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收藏
页码：191 / 195
页数：5
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