STUDIES ON CRUDE DRUGS EFFECTIVE ON VISCERAL LARVA MIGRANS .12. NEMATOCIDAL PRINCIPLES IN OAKMOSS ABSOLUTE AND NEMATOCIDAL ACTIVITY OF 2,4-DIHYDROXYBENZOATES

被引：32
作者：
AHAD, AM
GOTO, Y
KIUCHI, F
TSUDA, Y
KONDO, K
SATO, T
机构：
[1] KANAZAWA UNIV, FAC PHARMACEUT SCI, 13-1 TAKARA MACHI, KANAZAWA, ISHIKAWA 920, JAPAN
[2] TAKASAGO INT CORP, OHTA KU, TOKYO 144, JAPAN
[3] KANAZAWA UNIV, SCH MED, KANAZAWA, ISHIKAWA 920, JAPAN
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1991年 / 39卷 / 04期
关键词：
OAKMOSS ABSOLUTE; EVERNIA-PRUNASTRI; NEMATOCIDAL ACTIVITY; TOXOCARA-CANIS; DIHYDROXYBENZOATE; OCTYL 2,4-DIHYDROXYBENZOATE; STRUCTURE-ACTIVITY RELATIONSHIP;
D O I：
10.1248/cpb.39.1043
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Nematocidal principles obtained from oakmoss absolute were identified as methyl 2,4-dihydroxy-3,6-dimethylbenzoate (2), ethyl 3-formyl-2,4-dihydroxy-6-methylbenzoate (4), and ethyl 5-chloro-3-formyl-2,4-dihydroxy-6-methylbenzoate (7). In relation to their structures, the nematocidal activity of 2,4-dihydroxybenzoates of methyl to tetradecyl was tested and the strongest activity was found in the octyl ester (minimal lethal concentration = 13-mu-M).
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页码：1043 / 1046
页数：4
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