LOCALIZATION OF THE HUMAN GENE ENCODING THE CYTOSKELETAL PROTEIN TALIN TO CHROMOSOME 9P

被引：13

作者：

GILMORE, AP

OHANIAN, V

SPURR, NK

CRITCHLEY, DR

机构：

[1] UNIV LEICESTER,DEPT BIOCHEM,LEICESTER LE1 7RH,LEICS,ENGLAND

[2] IMPERIAL CANC RES FUND,CLARE HALL LABS,POTTERS BAR EN6 3LD,HERTS,ENGLAND

来源：

HUMAN GENETICS | 1995年 / 96卷 / 02期

关键词：

D O I：

10.1007/BF00207384

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The cytoskeletal protein talin is localised on the cytoplasmic face of the integrin family of adhesion receptors in cellular junctions with the extracellular matrix. Using polymerase chain reaction amplification and DNA from a panel of human-rodent somatic cell hybrids, we have assigned the talin gene to chromosome 9p. Deletions in 9p have been implicated in a variety of cancers, including malignant melanoma, and the concept that talin might be a candidate tumour suppressor gene is discussed.

引用

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页码：221 / 224

页数：4

相关论文

共 29 条

[11] THE CYTOSKELETAL PROTEIN TALIN CONTAINS AT LEAST 2 DISTINCT VINCULIN BINDING DOMAINS [J].

GILMORE, AP ;

WOOD, C ;

OHANIAN, V ;

JACKSON, P ;

PATEL, B ;

REES, DJG ;

HYNES, RO ;

CRITCHLEY, DR .

JOURNAL OF CELL BIOLOGY, 1993, 122 (02) :337-347

[12] SUPPRESSION OF TUMORIGENICITY IN SIMIAN-VIRUS 40-TRANSFORMED 3T3 CELLS TRANSFECTED WITH ALPHA-ACTININ CDNA [J].

GLUCK, U ;

KWIATKOWSKI, DJ ;

BENZEEV, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (02) :383-387

[13] CHROMOSOMAL LOCALIZATION OF HUMAN CELLULAR HOMOLOGS OF 2 VIRAL ONCOGENES [J].

HEISTERKAMP, N ;

GROFFEN, J ;

STEPHENSON, JR ;

SPURR, NK ;

GOODFELLOW, PN ;

SOLOMON, E ;

CARRITT, B ;

BODMER, WF .

NATURE, 1982, 299 (5885) :747-749

[14] INTERACTION OF PLASMA-MEMBRANE FIBRONECTIN RECEPTOR WITH TALIN - A TRANSMEMBRANE LINKAGE [J].

HORWITZ, A ;

DUGGAN, K ;

BUCK, C ;

BECKERLE, MC ;

BURRIDGE, K .

NATURE, 1986, 320 (6062) :531-533

[15]

JACKSON CW, 1993, BLOOD, V82, pA340

[16] A CELL-CYCLE REGULATOR POTENTIALLY INVOLVED IN GENESIS OF MANY TUMOR TYPES [J].

KAMB, A ;

GRUIS, NA ;

WEAVERFELDHAUS, J ;

LIU, QY ;

HARSHMAN, K ;

TAVTIGIAN, SV ;

STOCKERT, E ;

DAY, RS ;

JOHNSON, BE ;

SKOLNICK, MH .

SCIENCE, 1994, 264 (5157) :436-440

[17] DEVELOPMENT OF A PANEL OF MONOCHROMOSOMAL SOMATIC-CELL HYBRIDS FOR RAPID GENE-MAPPING [J].

KELSELL, DP ;

ROOKE, L ;

WARNE, D ;

BOUZYK, M ;

CULLIN, L ;

COX, S ;

WEST, L ;

POVEY, S ;

SPURR, NK .

ANNALS OF HUMAN GENETICS, 1995, 59 :233-241

[18] CYTOSKELETON PLASMA-MEMBRANE INTERACTIONS [J].

LUNA, EJ ;

HITT, AL .

SCIENCE, 1992, 258 (5084) :955-963

[19]

MUGURUMA M, 1992, J BIOL CHEM, V267, P5621

[20] DELETIONS OF THE CYCLIN-DEPENDENT KINASE-4 INHIBITOR GENE IN MULTIPLE HUMAN CANCERS [J].

NOBORI, T ;

MIURA, K ;

WU, DJ ;

LOIS, A ;

TAKABAYASHI, K ;

CARSON, DA .

NATURE, 1994, 368 (6473) :753-756