LOCALIZATION OF THE HUMAN GENE ENCODING THE CYTOSKELETAL PROTEIN TALIN TO CHROMOSOME 9P

被引：13

作者：

GILMORE, AP

OHANIAN, V

SPURR, NK

CRITCHLEY, DR

机构：

[1] UNIV LEICESTER,DEPT BIOCHEM,LEICESTER LE1 7RH,LEICS,ENGLAND

[2] IMPERIAL CANC RES FUND,CLARE HALL LABS,POTTERS BAR EN6 3LD,HERTS,ENGLAND

来源：

HUMAN GENETICS | 1995年 / 96卷 / 02期

关键词：

D O I：

10.1007/BF00207384

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The cytoskeletal protein talin is localised on the cytoplasmic face of the integrin family of adhesion receptors in cellular junctions with the extracellular matrix. Using polymerase chain reaction amplification and DNA from a panel of human-rodent somatic cell hybrids, we have assigned the talin gene to chromosome 9p. Deletions in 9p have been implicated in a variety of cancers, including malignant melanoma, and the concept that talin might be a candidate tumour suppressor gene is discussed.

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页码：221 / 224

页数：4

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