PROFOUNDLY DIFFERENT CALCIUM PERMEATION AND BLOCKAGE DETERMINE THE SPECIFIC FUNCTION OF DISTINCT CYCLIC NUCLEOTIDE-GATED CHANNELS

被引：231
作者：
FRINGS, S
SEIFERT, R
GODDE, M
KAUPP, UB
机构：
[1] Institut für Biologische Informationsverarbeitung Forschungszentrum Jülich, D-52425 Jülich
来源：
NEURON | 1995年 / 15卷 / 01期
关键词：
D O I：
10.1016/0896-6273(95)90074-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Sensory transduction in vertebrate photoreceptors and olfactory sensory neurons is mediated by cyclic nucleotide-gated (CNG) channels that conduct mono- and divalent cations. Ca2+ entering the cell through CNG channels intimately controls signaling pathways by regulating several key enzymes. Cloned CNG channels from photoreceptors and olfactory sensory neurons profoundly differ in their relative Ca2+ permeability, their blockage by external divalent cations, and the fraction of current carried by Ca2+. In particular, CNG channels from cone photoreceptors conduct significantly more Ca2+ than those from rod photoreceptors. Furthermore, the current through the olfactory CNG channel is entirely carried by Ca2+ at similar to 3 mM extracellular Ca2+. These results suggest that a major function of CNG channels is to provide a pathway for Ca2+ entry.
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页码：169 / 179
页数：11
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