PLATELET-ACTIVATING-FACTOR INHIBITS EXCITATORY TRANSMISSION IN RAT NEOSTRIATUM

被引:17
作者
JIANG, ZG [1 ]
YUE, TL [1 ]
FEUERSTEIN, G [1 ]
机构
[1] SMITHKLINE BEECHAM PHARAMACEUT,KING OF PRUSSIA,PA
关键词
PLATELET-ACTIVATING FACTOR; PRESYNAPTIC INHIBITION; GLUTAMATE RELEASE; BASAL GANGLIA; SYNAPTIC TRANSMISSION; MEMBRANE CURRENT;
D O I
10.1016/0304-3940(93)90690-M
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Platelet-activating factor (PAF) and its receptor have been found in mammalian brain but its neuronal action is unclear. Using brain slice and whole-cell patch-clamp techniques, it was found that PAF dose-dependently inhibited excitatory postsynaptic current in neostriatal neurons but not the current induced by exogenously applied glutamate. These effects were also observed with the synthetic agonist 2-methylcarbamyl-PAF and were blocked by BN50739, a competitive antagonist at PAF receptors. It is concluded that PAF acts presynaptically to inhibit the release of glutamate at excitatory synapses in the neostriatum.
引用
收藏
页码:132 / 135
页数:4
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