FREQUENCY OF DELETION FORMATION DECREASES EXPONENTIALLY WITH DISTANCE BETWEEN SHORT DIRECT REPEATS

被引：74

作者：

CHEDIN, F ^{[1
]}

DERVYN, E ^{[1
]}

DERVYN, R ^{[1
]}

EHRLICH, SD ^{[1
]}

NOIROT, P ^{[1
]}

机构：

[1] INRA, GENET MICROBIENNE LAB, F-78352 JOUY EN JOSAS, FRANCE

来源：

MOLECULAR MICROBIOLOGY | 1994年 / 12卷 / 04期

关键词：

D O I：

10.1111/j.1365-2958.1994.tb01042.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of distance between 18 bp direct repeats on deletion formation has been examined in Bacillus subtilis. The deletion frequency decreased exponentially by more than 1000-fold as the distance increased from 33 to 2313 bp. This decrease occurred in two distinct phases, which may be determined by DNA-duplex flexibility A similar relationship between deletion formation and distance was observed in a theta-replicating plasmid and in the chromosome, indicating that this relationship might have a general validity.

引用

页码：561 / 569

页数：9

共 59 条

[1] 2 DISTINCT MECHANISMS FOR DELETION IN MITOCHONDRIAL-DNA OF SCHIZOSACCHAROMYCES-POMBE MUTATOR STRAINS - SLIPPED MISPAIRING MEDIATED BY DIRECT REPEATS AND ERRONEOUS INTRON SPLICING [J].

AHNE, A ;

MULLERDERLICH, J ;

MERLOSLANGE, AM ;

KANBAY, F ;

WOLF, K ;

LANG, BF .

JOURNAL OF MOLECULAR BIOLOGY, 1988, 202 (04) :725-734

[2] ON THE FORMATION OF SPONTANEOUS DELETIONS - THE IMPORTANCE OF SHORT SEQUENCE HOMOLOGIES IN THE GENERATION OF LARGE DELETIONS [J].

ALBERTINI, AM ;

HOFER, M ;

CALOS, MP ;

MILLER, JH .

CELL, 1982, 29 (02) :319-328

[3]

ALBERTINI AM, 1982, COLD SPRING HARB SYM, V47, P841

[4] SEQUENCE HOMOLOGY REQUIREMENTS FOR INTERMOLECULAR RECOMBINATION IN MAMMALIAN-CELLS [J].

AYARES, D ;

CHEKURI, L ;

SONG, KY ;

KUCHERLAPATI, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (14) :5199-5203

[5] RECA-INDEPENDENT AND RECA-DEPENDENT INTRAMOLECULAR PLASMID RECOMBINATION - DIFFERENTIAL HOMOLOGY REQUIREMENT AND DISTANCE EFFECT [J].

BI, X ;

LIU, LF .

JOURNAL OF MOLECULAR BIOLOGY, 1994, 235 (02) :414-423

[6]

BIRNBOIM HC, 1979, NUCLEIC ACIDS RES, V7, P1513

[7] TRANSLATIONAL ERRORS AS THE CAUSE OF MUTATIONS IN ESCHERICHIA-COLI [J].

BOE, L .

MOLECULAR AND GENERAL GENETICS, 1992, 231 (03) :469-471

[8] CONSTRUCTION AND CHARACTERIZATION OF NEW CLONING VEHICLES .2. MULTIPURPOSE CLONING SYSTEM [J].

BOLIVAR, F ;

RODRIGUEZ, RL ;

GREENE, PJ ;

BETLACH, MC ;

HEYNEKER, HL ;

BOYER, HW ;

CROSA, JH ;

FALKOW, S .

GENE, 1977, 2 (02) :95-113

[9] PLASMID DELETION FORMATION BETWEEN SHORT DIRECT REPEATS IN BACILLUS-SUBTILIS IS STIMULATED BY SINGLE-STRANDED ROLLING-CIRCLE REPLICATION INTERMEDIATES [J].

BRON, S ;

HOLSAPPEL, S ;

VENEMA, G ;

PEETERS, BPH .

MOLECULAR AND GENERAL GENETICS, 1991, 226 (1-2) :88-96

[10] UNIDIRECTIONAL THETA REPLICATION OF THE STRUCTURALLY STABLE ENTEROCOCCUS-FAECALIS PLASMID PAM-BETA-1 [J].

BRUAND, C ;

EHRLICH, SD ;

JANNIERE, L .

EMBO JOURNAL, 1991, 10 (08) :2171-2177

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