INHIBITION OF WOUND CONTRACTION BY TOPICAL ANTIMICROBIALS

被引：35

作者：

LEITCH, IOW

KUCUKCELEBI, A

ROBSON, MC

机构：

[1] ROYAL ADELAIDE HOSP,DEPT PLAST & RECONSTRUCT SURG,ADELAIDE,SA 5000,AUSTRALIA

[2] UNIV TEXAS,MED BRANCH,DIV PLAST SURG,GALVESTON,TX 77550

来源：

AUSTRALIAN AND NEW ZEALAND JOURNAL OF SURGERY | 1993年 / 63卷 / 04期

关键词：

MAFENIDE; RATS; SILVER SULFADIAZINE; WOUND HEALING;

D O I：

10.1111/j.1445-2197.1993.tb00385.x

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Spontaneous wound healing occurs partly by wound contraction, a process that requires intact functioning fibroblasts, and collagen production. Disruption of fibroblasts by the topical antimicrobials, silver sulfadiazine and mafenide acetate has been demonstrated in vitro. An acute rat wound model was used to show that wound contraction in vivo is significantly impeded by silver sulfadiazine and mafenide acetate.

引用

页码：289 / 293

页数：5

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