MAPPING OF THE GENE FOR INTERFERON-INDUCIBLE DSRNA-DEPENDENT PROTEIN-KINASE TO CHROMOSOME REGION 2P21-22 - A SITE OF REARRANGEMENTS IN MYELOPROLIFERATIVE DISORDERS

被引：15
作者：
HANASH, SM
BERETTA, L
BARCROFT, CL
SHELDON, S
GLOVER, TW
UNGAR, D
SONENBERG, N
机构：
[1] UNIV MICHIGAN,SCH MED,DEPT PEDIAT,ANN ARBOR,MI 48104
[2] UNIV MICHIGAN,SCH MED,DEPT PATHOL,ANN ARBOR,MI 48104
[3] UNIV MICHIGAN,SCH MED,DEPT HUMAN GENET,ANN ARBOR,MI 48104
[4] UNIV MICHIGAN,SCH MED,CTR HUMAN GENOME,ANN ARBOR,MI 48104
[5] MCGILL UNIV,DEPT BIOCHEM,MONTREAL H3A 2T5,QUEBEC,CANADA
来源：
GENES CHROMOSOMES & CANCER | 1993年 / 8卷 / 01期
关键词：
D O I：
10.1002/gcc.2870080107
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recent evidence suggests that the human interferon-inducible double-stranded RNA-dependent protein kinase may function as a tumor suppressor. Here we describe the mapping of the gene for this kinase to chromosome region 2p21-22 by fluorescence in situ hybridization. A combined analysis of cytogenetic data from a series of 341 patients with hematologic disorders that exhibited cytogenetic abnormalities and from published reports indicates that abnormalities involving 2p21-22 occur nonrandomly and are observed among patients with acute myelogenous leukemia, raising the possibility of a role for this protein kinase in leukemogenesis. (C) 1993 Wiley-Liss, Inc.
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页码：34 / 37
页数：4
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