SIMULTANEOUS RENAL AND INTRAPERITONEAL SEGMENTAL PANCREATIC TRANSPLANTATION - THE ZURICH EXPERIENCE

Simultaneous renal and i.p. segmental pancreas transplantation with a prolamine-occluded duct was performed in 15 type I diabetics with end-stage renal failure. Four pancreas grafts are currently functioning at 2 days, 2 wk, 30 and 39 mo. In 3 patients, both organs were rejected within 6 mo.; 2 patients died with functioning grafts at 36 h and 2 mo. In 6 patients pancreatic failure for nonimmunological reasons did not jeopardize the simultaneous kidney graft. No adverse effects of duct occlusion with prolamine could be demonstrated. Simultaneous renal and pancreatic transplantation is the method of choice in most patients with complicated type I diabetes and end-stage renal failure.