SYNTHESIS AND ANTIMICROBIAL ACTIVITY EVALUATION OF SOME SCHIFF BASES DERIVED FROM 2-AMINOTHIAZOLE DERIVATIVES

被引：0
|
作者：
Gupta, Rajul [1 ]
Fuloria, Neeraj Kumar [2 ]
Fuloria, Shivkanya [2 ]
机构：
[1] CMJ Univ, Modrina Mans Laitumkhrah, Shillong 793003, Meghalaya, India
[2] Anuradha Coll Pharm, Dept Pharmaceut Chem, Buldana, Maharashtra, India
来源：
INDONESIAN JOURNAL OF PHARMACY | 2013年 / 24卷 / 03期
关键词：
thiazole; acetophenones; antibacterial; antifungal; substituted aldehydes;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Various substituted acetophenones (1-5) on treatment with iodine and thiourea yielded 2-amino-4-(substituted-phenyl)thiazole (1a-5a), which on further treatment with various substituted aldehydes to get N-(substitutedbenzylidene)-4( substitutedphenyl) thiazol-2-amine (1b-5b). All the synthesized compounds were characterized by their respective FTIR, 1H NMR and mass data. Synthesized compounds (1b-5b) were subjected to investigation for their antibacterial and antifungal studies against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Asperigillus flavus and Asperigillus fumigatus by disk diffusion method. Compound 5b was found to be most effective with largest zone of inhibition.
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页码：193 / 197
页数：5
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