INSULIN-MEDIATED REDUCTION OF WHOLE-BODY PROTEIN BREAKDOWN - DOSE-RESPONSE EFFECTS ON LEUCINE METABOLISM IN POST-ABSORPTIVE MEN

被引：351
作者：
FUKAGAWA, NK
MINAKER, KL
ROWE, JW
GOODMAN, MN
MATTHEWS, DE
BIER, DM
YOUNG, VR
机构：
[1] MIT,DEPT APPL BIOL SCI,CAMBRIDGE,MA 02139
[2] MIT,CLIN RES CTR,CAMBRIDGE,MA 02139
[3] BETH ISRAEL HOSP,CHARLES A DANA RES INST,BOSTON,MA 02215
[4] BETH ISRAEL HOSP,HARVARD THORNDIKE LAB,BOSTON,MA 02215
[5] BRIGHAM & WOMENS HOSP,DEPT MED,BOSTON,MA 02115
[6] HARVARD UNIV,DIV AGING,BOSTON,MA 02215
[7] WASHINGTON UNIV,DEPT MED & PEDIAT,ST LOUIS,MO 63110
[8] BOSTON UNIV,SCH MED,DEPT MED & PHYSIOL,BOSTON,MA 02118
[9] BROCKTON N ROXBURY VET ADM MED CTR,CTR GERIATR RES EDUC CLIN,BOSTON,MA 02215
来源：
JOURNAL OF CLINICAL INVESTIGATION | 1985年 / 76卷 / 06期
关键词：
D O I：
10.1172/JCI112240
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
引用
收藏
页码：2306 / 2311
页数：6
相关论文
共 46 条
[1]   ROLE OF INSULIN IN THE REGULATION OF LEUCINE KINETICS IN THE CONSCIOUS DOG [J].
ABUMRAD, NN ;
JEFFERSON, LS ;
RANNELS, SR ;
WILLIAMS, PE ;
CHERRINGTON, AD ;
LACY, WW .
JOURNAL OF CLINICAL INVESTIGATION, 1982, 70 (05) :1031-1041
[2]   TRACER PRIMING BICARBONATE POOL [J].
ALLSOP, JR ;
WOLFE, RR ;
BURKE, JF .
JOURNAL OF APPLIED PHYSIOLOGY, 1978, 45 (01) :137-139
[3]   INVIVO MEASUREMENT OF GLUCOSE AND ALANINE METABOLISM WITH STABLE ISOTOPIC TRACERS [J].
BIER, DM ;
ARNOLD, KJ ;
SHERMAN, WR ;
HOLLAND, WH ;
HOLMES, WF ;
KIPNIS, DM .
DIABETES, 1977, 26 (11) :1005-1015
[4]  
Block RJ., 1956, AMINO ACID HDB, P341
[5]   PUMP-INDUCED INSULIN AGGREGATION - A PROBLEM WITH THE BIOSTATOR [J].
BRENNAN, JR ;
GEBHART, SSP ;
BLACKARD, WG .
DIABETES, 1985, 34 (04) :353-359
[6]   MUSCLE PROTEIN-SYNTHESIS - REGULATION OF A TRANSLATIONAL INHIBITOR [J].
BUSE, MG ;
CHEEMA, IR ;
OWENS, M ;
LEDFORD, BE ;
GALBRAITH, RA .
AMERICAN JOURNAL OF PHYSIOLOGY, 1984, 246 (06) :E510-E515
[7]   OXIDATION OF LEUCINE BY RAT LIVER AND KIDNEY [J].
DAWSON, AG ;
HIRD, FJR ;
MORTON, DJ .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1967, 122 (02) :426-&
[8]  
DEFRONZO RA, 1979, AM J PHYSIOL, V237, pE214
[9]   THE EFFECT OF INSULIN ON THE DISPOSAL OF INTRAVENOUS GLUCOSE - RESULTS FROM INDIRECT CALORIMETRY AND HEPATIC AND FEMORAL VENOUS CATHETERIZATION [J].
DEFRONZO, RA ;
JACOT, E ;
JEQUIER, E ;
MAEDER, E ;
WAHREN, J ;
FELBER, JP .
DIABETES, 1981, 30 (12) :1000-1007
[10]   LEUCINE UPTAKE BY SPLANCHNIC AND LEG TISSUES IN MAN - RELATIVE INDEPENDENCE OF INSULIN LEVELS [J].
ERIKSSON, LS ;
HAGENFELDT, L ;
FELIG, P ;
WAHREN, J .
CLINICAL SCIENCE, 1983, 65 (05) :491-498
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