[H-3]YOHIMBINE AND [H-3]IDAZOXAN BIND TO DIFFERENT SITES ON RABBIT FOREBRAIN AND KIDNEY MEMBRANES

被引：104
作者：
HAMILTON, CA
REID, JL
YAKUBU, MA
机构：
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1988年 / 146卷 / 2-3期
关键词：
D O I：
10.1016/0014-2999(88)90314-7
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The binding of the .alpha.2-adrenoceptor ligands [3H]yohimbine and [3H]idazoxan to rabbit kidney and forebrain membranes was compared. The maximum number of [3H]yohibine binding sites was higher than the number of [3H]idazoxan binding sites in forebrain and lower in kidney. Large differences were observed in the ability of noradrenaline, adrenaline, idazoxan, rauwolscine, yohimbine and WY 26392 to displace [3H]yohimbine and [3H]idazoxan from their binding sites. These data suggest that [3H]idazoxan and [3H]yohimbine bind to different sites on rabbit tissue membranes.
引用
收藏
页码：345 / 348
页数：4
相关论文
共 50 条
[41]   MONOAMINERGIC INTERACTIONS IN THE WEAVER MOUSE NEOSTRIATUM - SYNAPTOSOMAL UPTAKE OF [H-3] DOPAMINE AND [H-3] SEROTONIN AND VISUALIZATION OF UPTAKE SITES WITH [H-3] MAZINDOL AND [H-3] CITALOPRAM BINDING AUTORADIOGRAPHY [J].
STOTZ, EH ;
TRIARHOU, LC ;
GHETTI, B ;
NORTON, J ;
SIMON, JR ;
LANDWEHRMEYER, B ;
PALACIOS, JM .
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1993, 52 (03) :294-294
[42]   EFFECT OF PROTEASES AND PHOSPHOLIPASES ON [H-3] YOHIMBINE BINDING TO HUMAN-PLATELET MEMBRANES [J].
PERIYASAMY, S ;
SOMANI, P .
BIOCHEMICAL PHARMACOLOGY, 1986, 35 (18) :3131-3136
[43]   IDENTIFICATION OF ALPHA-ADRENOCEPTOR SUBTYPES IN DOG ARTERIES BY (H-3)-LABELED YOHIMBINE AND (H-3)-LABELED PRAZOSIN [J].
BOBIK, A .
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 1982, 9 (04) :403-404
[44]   (H-3) SPIROPERIDOL BINDING-SITES IN THE RABBIT SPLENIC ARTERY [J].
AMENTA, F ;
CANTAGALLI, A ;
CAVALLOTTI, C ;
MIONE, MC ;
SANCESARIO, G .
BASIC RESEARCH IN CARDIOLOGY, 1984, 79 (01) :80-85
[45]   CHARACTERIZATION OF (H-3)NIFEDIPINE BINDING-SITES IN RABBIT MYOCARDIUM [J].
HOLCK, M ;
THORENS, S ;
HAEUSLER, G .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1982, 85 (3-4) :305-315
[46]   Presynaptic imidazoline receptors and [H-3]idazoxan binding sites in human right atrium. [J].
Molderings, GJ ;
Likungu, J ;
Gothert, M .
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1996, 354 (04) :33-33
[47]   PRODUCTION OF (H2O)-H-3 FROM H-3 GLUCOSE AS A MEASURE OF GLYCOLYSIS - TISSUE SITES OF (H2O)-H-3 RELEASE [J].
MANDARINO, L ;
WEISS, L ;
FINLAYSON, J ;
KELLEY, D .
CLINICAL RESEARCH, 1989, 37 (04) :A913-A913
[48]   [H-3] ANIRACETAM BINDS TO SPECIFIC RECOGNITION SITES IN BRAIN MEMBRANES [J].
FALLARINO, F ;
GENAZZANI, AA ;
SILLA, S ;
LEPISCOPO, MR ;
CAMICI, O ;
CORAZZI, L ;
NICOLETTI, F ;
FIORETTI, MC .
JOURNAL OF NEUROCHEMISTRY, 1995, 65 (02) :912-918
[49]   [H-3] SEROTONIN BINDING-SITES IN GOLDFISH RETINAL MEMBRANES [J].
LIMA, L ;
RADTKE, I ;
DRUJAN, B .
NEUROCHEMICAL RESEARCH, 1992, 17 (10) :991-996
[50]   DIFFERENT DENSITIES OF 5-HT(3) RECEPTORS ARE LABELED BY [H-3] QUIPAZINE, [H-3] GR-65630 AND [H-3] GRANISETRON [J].
WONG, EHF ;
BONHAUS, DW ;
LEE, JA ;
WU, I ;
LOURY, DN ;
EGLEN, RM .
NEUROPHARMACOLOGY, 1993, 32 (09) :869-875
12345