[H-3]YOHIMBINE AND [H-3]IDAZOXAN BIND TO DIFFERENT SITES ON RABBIT FOREBRAIN AND KIDNEY MEMBRANES

被引：104

作者：

HAMILTON, CA

REID, JL

YAKUBU, MA

机构：

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1988年 / 146卷 / 2-3期

关键词：

D O I：

10.1016/0014-2999(88)90314-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The binding of the .alpha.2-adrenoceptor ligands [3H]yohimbine and [3H]idazoxan to rabbit kidney and forebrain membranes was compared. The maximum number of [3H]yohibine binding sites was higher than the number of [3H]idazoxan binding sites in forebrain and lower in kidney. Large differences were observed in the ability of noradrenaline, adrenaline, idazoxan, rauwolscine, yohimbine and WY 26392 to displace [3H]yohimbine and [3H]idazoxan from their binding sites. These data suggest that [3H]idazoxan and [3H]yohimbine bind to different sites on rabbit tissue membranes.

引用

页码：345 / 348

页数：4

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