[H-3]YOHIMBINE AND [H-3]IDAZOXAN BIND TO DIFFERENT SITES ON RABBIT FOREBRAIN AND KIDNEY MEMBRANES

被引：104
|
作者：
HAMILTON, CA
REID, JL
YAKUBU, MA
机构：
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1988年 / 146卷 / 2-3期
关键词：
D O I：
10.1016/0014-2999(88)90314-7
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The binding of the .alpha.2-adrenoceptor ligands [3H]yohimbine and [3H]idazoxan to rabbit kidney and forebrain membranes was compared. The maximum number of [3H]yohibine binding sites was higher than the number of [3H]idazoxan binding sites in forebrain and lower in kidney. Large differences were observed in the ability of noradrenaline, adrenaline, idazoxan, rauwolscine, yohimbine and WY 26392 to displace [3H]yohimbine and [3H]idazoxan from their binding sites. These data suggest that [3H]idazoxan and [3H]yohimbine bind to different sites on rabbit tissue membranes.
引用
收藏
页码：345 / 348
页数：4
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