SYNTHESIS OF 2-(P-AMINOBENZYL) DERIVATIVES OF 1,4,7-TRIAZACYCLONONANE-N,N',N''-TRIACETIC ACID (NOTA) AND 1,4,7,10-TETRAAZACYCLODODECANE-N,N',N'',N'''-TETRAACETIC ACID (DOTA) - MACROCYCLIC BIFUNCTIONAL CHELATING-AGENTS USEFUL FOR ANTIBODIES LABELING

被引：8

作者：

ANSARI, MH ^{[1
]}

AHMAD, M ^{[1
]}

DICKE, KA ^{[1
]}

机构：

[1] UNIV NEBRASKA, MED CTR, CTR CLIN CANC, OMAHA, NE 68198 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(00)80288-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A convenient synthesis of above titled p-aminobenzyl derivatives of NOTA (9) and DOTA (14) are described which is based on a modified Richman-Atkins type macrocyclization between tritosylamide (2) derived from p-nitrophenylalanine, and dimesylates (3) and (4) derived from ethylene glycol and N-toluene-p-sulfonyldiethanolamine, respectively.

引用

页码：1067 / 1070

页数：4

共 20 条

[1] GD-DOTA - CHARACTERIZATION OF A NEW PARAMAGNETIC COMPLEX [J].

BOUSQUET, JC ;

SAINI, S ;

STARK, DD ;

HAHN, PF ;

NIGAM, M ;

WITTENBERG, J ;

FERRUCCI, JT .

RADIOLOGY, 1988, 166 (03) :693-698

[2] BACKBONE-SUBSTITUTED DTPA LIGANDS FOR Y-90 RADIOIMMUNOTHERAPY [J].

BRECHBIEL, MW ;

GANSOW, OA .

BIOCONJUGATE CHEMISTRY, 1991, 2 (03) :187-194

[3] SYNTHESIS OF 1-(PARA-ISOTHIOCYANATOBENZYL) DERIVATIVES OF DTPA AND EDTA - ANTIBODY LABELING AND TUMOR-IMAGING STUDIES [J].

BRECHBIEL, MW ;

GANSOW, OA ;

ATCHER, RW ;

SCHLOM, J ;

ESTEBAN, J ;

SIMPSON, DE ;

COLCHER, D .

INORGANIC CHEMISTRY, 1986, 25 (16) :2772-2781

[4] SYNTHESIS OF A KINETICALLY STABLE Y-90 LABELED MACROCYCLE ANTIBODY CONJUGATE [J].

COX, JPL ;

JANKOWSKI, KJ ;

KATAKY, R ;

PARKER, D ;

BEELEY, NRA ;

BOYCE, BA ;

EATON, MAW ;

MILLAR, K ;

MILLICAN, AT ;

HARRISON, A ;

WALKER, C .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1989, (12) :797-798

[5] SYNTHESIS OF C-FUNCTIONALIZED AND N-FUNCTIONALIZED DERIVATIVES OF 1,4,7-TRIAZACYCLONONANE-1,4,7-TRIYLTRIACETIC ACID (NOTA), 1,4,7,10-TETRA-AZACYCLODODECANE-1,4,7,10-TETRAYLTETRA-ACETIC ACID (DOTA), AND DIETHYLENENETRIAMINEPENTA-ACETIC ACID (DTPA) - BIFUNCTIONAL COMPLEXING AGENTS FOR THE DERIVATIZATION OF ANTIBODIES [J].

COX, JPL ;

CRAIG, AS ;

HELPS, IM ;

JANKOWSKI, KJ ;

PARKER, D ;

EATON, MAW ;

MILLICAN, AT ;

MILLAR, K ;

BEELEY, NRA ;

BOYCE, BA .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1990, (09) :2567-2576

[6] TOWARDS TUMOR IMAGING WITH IN-111 LABELED MACROCYCLE ANTIBODY CONJUGATES [J].

CRAIG, AS ;

HELPS, IM ;

JANKOWSKI, KJ ;

PARKER, D ;

BEELEY, NRA ;

BOYCE, BA ;

EATON, MAW ;

MILLICAN, AT ;

MILLAR, K ;

PHIPPS, A ;

RHIND, SK ;

HARRISON, A ;

WALKER, C .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1989, (12) :794-796

[7] STABILITY, GA-71 NMR, AND CRYSTAL-STRUCTURE OF A NEUTRAL GALLIUM(III) COMPLEX OF 1,4,7-TRIAZACYCLONONANETRIACETATE - A POTENTIAL RADIOPHARMACEUTICAL [J].

CRAIG, AS ;

PARKER, D ;

ADAMS, H ;

BAILEY, NA .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1989, (23) :1793-1794

[8] A CONVENIENT SYNTHESIS OF BIFUNCTIONAL CHELATING-AGENTS BASED ON DIETHYLENETRIAMINEPENTAACETIC ACID AND THEIR COORDINATION CHEMISTRY WITH YTTRIUM(III) [J].

CUMMINS, CH ;

RUTTER, EW ;

FORDYCE, WA .

BIOCONJUGATE CHEMISTRY, 1991, 2 (03) :180-186

[9]

JORDIS U, 1990, SYNTHESIS-STUTTGART, P925

[10]

KOZAK RW, 1989, CANCER RES, V49, P2639

← 1 2 →