Glucose-sensitive insulin-releasing molecular systems

被引：18
|
作者：
Imanishi, Y
Ito, Y
机构：
[1] Division of Material Chemistry, Faculty of Engineering Kyoto University, Kyoto
来源：
PURE AND APPLIED CHEMISTRY | 1995年 / 67卷 / 12期
关键词：
D O I：
10.1351/pac199567122015
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Three types of molecular systems for insulin release in response to glucose were designed and synthesized. i) Chemical valve was synthesized by immobilization of glucose oxidase onto poly(acrylic acid)-grafted porous membrane. ii) Membrane device was constructed by immobilization of insulin through disulfide linkage with combination of glucose dehydrogenase and electron mediators. iii) Enzyme device was made by coupling glucose oxidase and insulin through disulfide linkage.
引用
收藏
页码：2015 / 2021
页数：7
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