THE RETINOBLASTOMA PROTEIN AND CELL-CYCLE REGULATION

被引：56
作者：
HAMEL, PA
GALLIE, BL
PHILLIPS, RA
机构：
[1] UNIV TORONTO, DEPT OPTHALMOL & IMMUNOL, TORONTO M5S 1A1, ONTARIO, CANADA
[2] HOSP SICK CHILDREN, DIV IMMUNOL & CANC RES, TORONTO M5G 1X8, ONTARIO, CANADA
来源：
TRENDS IN GENETICS | 1992年 / 8卷 / 05期
关键词：
D O I：
10.1016/0168-9525(92)90221-O
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Although the precise function of the retinoblastoma gene product, p110RB1, remains unknown, recent data suggest that it plays a role in the control of cellular proliferation by regulating transcription of genes required for a cell to enter or stay in a quiescent or G0 state, or for progression through the G1 phase of the cell cycle. However, it is difficult to rationalize the expression of p110RB1 in a wide range of tissues with the fact that mutations in the RB1 gene initiate cancers in a limited number of tissues.
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收藏
页码：180 / 185
页数：6
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