THE IMPORTANCE OF MOSAIC GENES TO TRYPANOSOME SURVIVAL

被引：39
作者：
BARBET, AF
KAMPER, SM
机构：
[1] Department of Infectious Diseases, University of Florida, Gainesville, FL 32611-0880
来源：
PARASITOLOGY TODAY | 1993年 / 9卷 / 02期
关键词：
D O I：
10.1016/0169-4758(93)90039-I
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
African trypanosomes possess several elegant ways to evade the immune defenses of mammalian hosts. They have an extensive repertoire of genes for a variant surface antigen and recent data show that this finite repertoire can be further amplified by mosaic gene formation and point mutation, producing an almost limitless capacity to vary. The significance of these mechanisms of antigenic diversity to trypanosome biology and the parasite-host relationship in general are discussed here by Anthony Barbet and Sondra Kamper.
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页码：63 / 66
页数：4
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