LONG-TERM RESULTS OF COMBINED CHEMOTHERAPY-RADIOTHERAPY APPROACH IN HODGKINS-DISEASE - SUPERIORITY OF ABVD PLUS RADIOTHERAPY VERSUS MOPP PLUS RADIOTHERAPY

被引：316

作者：

SANTORO, A ^{[1
]}

BONADONNA, G ^{[1
]}

VALAGUSSA, P ^{[1
]}

ZUCALI, R ^{[1
]}

VIVIANI, S ^{[1
]}

VILLANI, F ^{[1
]}

PAGNONI, AM ^{[1
]}

BONFANTE, V ^{[1
]}

MUSUMECI, R ^{[1
]}

CRIPPA, F ^{[1
]}

TESS, JDT ^{[1
]}

BANFI, A ^{[1
]}

机构：

[1] IST NAZL TUMORI, VIA VENEZIAN 1, I-20133 MILAN, ITALY

来源：

JOURNAL OF CLINICAL ONCOLOGY | 1987年 / 5卷 / 01期

关键词：

D O I：

10.1200/JCO.1987.5.1.27

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In an attempt to reduce some of the delayed sequelae associated with combined modality therapy in Hodgkin''s disease, we randomly tested stages IIB, IIIA, and IIIB MOPP (mechlorethamine, vincristine, procarbazine, and prednisone) v ABVD (Adriamycin, bleomycin, vinblastine, and dacarbazine). In 232 previously untreated patients, three cycles of either combination preceded and followed extensive irradiation. The complete remission rate was 80.7% following MOPP and 92.4% following ABVD (P < .02). The 7-year results indicated that ABVD was superior to MOPP in terms of freedom from progression (80.8% v 62.8%; P < .002), relapse-free survival (87.7% v 77.2%; P = .06), and overall survival (77.4% v 67.9%; P = .03). Moreover, the comparative iatrogenic morbidity showed that irreversible gonadal dysfunction as well as acute leukemia occurred only in patients subjected to MOPP, while cardiopulmonary studies failed to document significant laboratory differences between the two treatment groups. Present findings indicate that ABVD followed by extensive irradiation represents a valid therapeutic alternative to the widely used alkylating agent-containing regimens plus radiotherapy.

引用

页码：27 / 37

页数：11

共 36 条

[1] BCVPP CHEMOTHERAPY FOR ADVANCED HODGKINS-DISEASE - EVIDENCE FOR GREATER DURATION OF COMPLETE REMISSION, GREATER SURVIVAL, AND LESS TOXICITY THAN WITH A MOPP REGIMEN [J].