FACTORS INFLUENCING THE STABILITY OF RANITIDINE IN TPN MIXTURES

被引：10

作者：

ALLWOOD, MC

MARTIN, H

机构：

[1] Medicines Research Unit, University of Derby, Mickleover, Derby

来源：

CLINICAL NUTRITION | 1995年 / 14卷 / 03期

关键词：

D O I：

10.1016/S0261-5614(95)80016-6

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The stability of ranitidine in TPN mixtures has been widely studied with varying results. The evidence suggests that ranitidine is unstable and should be added within 24 h of administration, although other reports indicate ranitidine is stable for at least 14 days. The causes of ranitidine degradation in TPN mixtures were therefore studied in mixtures without fat emulsion using a stability-indicating HPLC method. The results indicated that the stability of ranitidine at 5 degrees C depended on the commercial source of amino acid, additives and type of bag used. The principle mechanism of degradation was identified as oxidation. Ranitidine was more stable in EVA bags in the absence of the trace element additive, which appeared to accelerate ranitidine oxidation. Ranitidine was most stable in mixtures compounded in multi-layered bags. The results suggest TPN mixtures with ranitidine in multi-layered bags could be assigned shelf lives of at least 14 days at 5 degrees C, depending on the amino acid infusion used in the regimen.

引用

页码：171 / 176

页数：6

共 13 条

[1]

Rosenberg, Dougherty, Mayron, Baldinus, Cimetidine compatibility. I: Chemical aspects and room temperature stability in intravenous infusions, Am J Hosp Pharm, 37, pp. 390-392, (1980)

[2]

Yuhas, Lofton, Mayron, Baldinus, Rosenberg, Cimetidine hydrochloride compatibility. II: Room temperature stability in intravenous infusion fluids, Am J Hosp Pharm, 38, pp. 879-881, (1981)

[3]

Grimble, Hunjan, Payne-James, Silk, Long-term stability of ranitidine in total parenteral nutrition solutions: effects on lipid emulsion stability, Br J Int Care, 1, pp. 32-36, (1991)

[4]

Galante, Stewart, Warren, Johnson, Duncan, Stability of ranitidine hydrochloride at dilute concentration in intravenous infusion fluids at room temperature, Am J Hosp Pharm, 47, pp. 1580-1584, (1991)

[5]

Allwood, Effect of reducing agents on the stability of ranitidine in TPN, Proceedings, (1993)

[6]

McElroy, Wiggens, Hardy, Stability of ranitidine-containing All-In-One (A-I-O) parenteral nutrition mixtures, Clin Nutr, 8, (1991)

[7]

Williams, Hak, Dukes, In vitro evaluation of the stability of ranitidine hydrochloride in total parenteral nutrient mixtures, Am J Hosp Pharm, 47, pp. 1574-1579, (1990)

[8]

Cano, Montoro, Pastor, Pon, Sabin, Stability of ranitidine hydrochloride in total nutrient admixtures, Am J Hosp Pharm, 45, pp. 1100-1102, (1988)

[9]

Montoro, Pon, Comment on the stability of ranitidine hydrochloride in total nutrient admixtures, Am J Hosp Pharm, 48, (1991)

[10]

Walker, Bayliff, Stability of ranitidine hydrochloride in total parenteral nutrient solutions, Am J Hosp Pharm, 42, pp. 590-593, (1985)

← 1 2 →