ACUTE QUADRIPLEGIC MYOPATHY - A COMPLICATION OF TREATMENT WITH STEROIDS, NONDEPOLARIZING BLOCKING-AGENTS, OR BOTH

被引：179

作者：

HIRANO, M

OTT, BR

RAPS, EC

MINETTI, C

LENNIHAN, L

LIBBEY, NP

BONILLA, E

HAYS, AP

机构：

[1] ROGER WILLIAMS GEN HOSP,DEPT NEUROL & PATHOL,PROVIDENCE,RI

[2] HOSP UNIV PENN,DEPT NEUROL,PHILADELPHIA,PA 19104

来源：

NEUROLOGY | 1992年 / 42卷 / 11期

关键词：

D O I：

10.1212/WNL.42.11.2082

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We studied two patients who were given high-dose intravenous steroid therapy and were intubated for status asthmaticus. Both became quadriplegic and wasted within 2 weeks. EMG had myopathic abnormalities. Muscle biopsy revealed severe atrophy of most muscle fibers, with disorganization of myofibrils and selective loss of thick (myosin) filaments. Immunohistologic stains for myosin isoforms confirmed the decrease or absence of this protein. Both patients clinically improved over several months.

引用

页码：2082 / 2087

页数：6

共 26 条

[1] STEROID MYOPATHY IN CONNECTIVE-TISSUE DISEASE [J].