EFFICIENT PATHWAYS TO (R)-5-HYDROXYMETHYL-2-OXAZOLIDINONE AND (S)-5-HYDROXYMETHYL-2-OXAZOLIDINONE AND SOME DERIVATIVES

被引：46
作者：
DANIELMEIER, K [1 ]
STECKHAN, E [1 ]
机构：
[1] UNIV BONN,INST ORGAN CHEM & BIOCHEM,D-53121 BONN,GERMANY
来源：
TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 05期
关键词：
D O I：
10.1016/0957-4166(95)00144-E
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
2-Oxazolidinones are a very interesting class of compounds due to their various pharmacological effects. Two new syntheses of enantiomerically pure (R)- and (S)-5-hydrolymethyl-2-oxazolidinone have been developed starting with D- mannitol, L-ascorbic acid and (R)- or (S)-malic acid. (R)- and (S)-5-hydroxylmethyl-2-oxazolidinone have been used to synthesize some new homochiral 2-oxazolidinone derivatives.
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页码：1181 / 1190
页数：10
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